Xiaohua Liu, PhD

Biography

Career History

• Adjunct Professor, Texas A&M College of Dentistry (2021-present)
• Associate Professor, Texas A&M College of Dentistry (2016 - 2021)
• Assistant Professor,  Baylor College of Dentistry/Texas A&M College of Dentistry (2010 - 2016)

Teaching Interests

• Nano-Biomaterials and Regenerative Medicine (Course Director)
• Responsible Conduct in Biomedical Research (Course Director)
• Cell and Molecular Biology of Oral and Craniofacial Tissues II (Co-Course Director)
• Microscopy, Imaging, and Associated Techniques (Co-course Director)

Research Interests

The research in my lab focuses on the development of bio-inspired materials and nanotechnologies for tissue regeneration and controlled drug delivery. Specifically, we are interested in 1) Design and synthesis of novel biomaterials and bio-responsive drug delivery systems; 2) Development of biomimetic 3D platforms to control stem cell fates; and 3) Regeneration of dental and craniofacial tissues.

Recent Grants

• NIH/NIDCR DE029808                                                          Liu (PI)           4/2021 - 3/2026
• NIH/NIDCR DE024979                                                          Liu (PI)           7/2020-6/2022
• NIH/NIAMS AR078311                                                          Liu (CO-I)       7/2021-3/2026
• NIH/NIDCR AR078311                                                          Liu (Co-I)       7/2021-3/2026
• NIH/NIDCR DE024979                                                          Liu (PI)          7/2016-6/2022
• NIH/NIDCR DE019463                                                          Liu (Co-I)       7/2017-4/2022
• CPRIT RP170179                                                                  Liu (Co-PI)    8/2017-8/2021

Recent Selected Publications

1. 1. Chang B, Ma C, Feng J, Svoboda K, and Liu X (2021). “Dental pulp stem cell polarization: effects of biophysical factors” Journal of Dental Research, 100:1153-1160. PMID: 34328032
   2. Liang Y, Hu Z, Li Q, and Liu X (2021). “Pyrophosphate inhibits periodontal ligament stem cell differentiation and mineralization through MAPK signaling pathways” Journal of Periodontology Research, 56:982–990, PMID: 34142719
   3. Li Q, Hu Z, Rong X, Chang B, and Liu X (2021). “Multifunctional polyplex micelles for efficient microRNA delivery and accelerated osteogenesis” Nanoscale, 3: 12198–12211, PMID: 34231613
   4. Chang B and Liu X (2021). “Osteon: structure, turnover and regeneration” Tissue Engineering Part B, 2021, doi: 10.1089/ten.TEB.2020.0322, PMID: 33487116
   5. Li Q, Hu Z, Liang Y, and Liu X (2021). “Multifunctional peptide-conjugated non-viral gene delivery for vascularized pulp regeneration in a full-length human tooth root” Acta Biomaterialia, 127: 252-265 PMID: 33813092.
   6. Chang B, Ma C, and Liu X (2020). “Nanofibrous tubular three-dimensional platform for single dental pulp stem cell polarization” ACS Applied Materials & Interfaces, 12: 54481-54488, PMID: 33252216.
   7. Wu R, Ma C, Liang Y, Chen F, and Liu X (2020). “ECM-mimicking nanofibrous matrix coaxes macrophages toward an anti-inflammatory phenotype: Cellular behaviors and transcriptome analysis” Applied Materials Today, 100508, PMCID: PMC7450828
   8. Liang Y, Luan X, and Liu X (2020). “Recent advances in periodontal regeneration: A biomaterial perspective” Bioactive Materials, 5:297-308, PMCID: PMC7052441
   9. Hu Z, Ma C, Liang Y, Zou S, and Liu X (2019). “Osteoclasts in bone regeneration under type 2 diabetes mellitus” Acta Biomaterialia, 84:402-413. PMCID: PMC6326860
   10. Chang B, Svoboda K, and Liu X (2019). “Cell polarization: From epithelial cells to odontoblasts” International Journal of Oral Science, 98:1-11. PMCID: PMC6338482
   11. Ma C, Chang B, Jing Y, Kim H, and Liu X (2018). “Bio-inspired micropatterned platforms recapitulate 3D physiological morphologies of bone and dentinal cells” Advanced Sciences, 5:1801037, PMCID:PMC6299721
   12. Chang B, Ma C, and Liu X (2018). “Nanofibers regulate single bone marrow stem cell osteogenesis via FAK/RhoA/YAP1 pathway” ACS Applied Materials & Interfaces, 10:33022-33031. PMCID: PMC6436105
   13. Hu Z, Ma C, Rong X, Zou S, and Liu X (2018). “Immunomodulatory ECM-like microspheres for accelerated bone regeneration in diabetes mellitus” ACS Applied Materials & Interfaces, 10:2377-2390. PMID: 29280610.
   14. Ma C, Qu T, Chang B, Jing Y, Feng JQ, and Liu X. (2018) “3D maskless micropatterning for regeneration of highly organized tubular tissues” Advanced Healthcare Materials, 7: 1700738, PMCID: PMC5803393.
   15. Chang B, Ahuja N, Ma C, and Liu X. (2017) “Injectable scaffolds for dental and craniofacial regeneration” Materials Science & Engineering R: Reports, 111:1-26. PMCID: PMC5478172.

        

       Complete List of Published Work in myBibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/xiaohua.liu.2/bibliography/45484534/public/?sort=date&direction=ascending

       Or in Google Scholar: http://scholar.google.com/citations?user=PQmfou8AAAAJ&hl=en

    

National Service/Recognition

• Standing member of NIH ODCS study section (2021-2025)
• Program chair of Society for Biomaterials Dental/Craniofacial Special Interest Group (2015-Present)
• Ad hoc reviewer for 33 journals (2013-present)
• Editorial board member of Journal of Dental Research (2016-2022)
• 28 invited talks (nationally and internationally) (2013-2021)