Chunlin Qin, PhD, DDS, MS

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2024 FAM20A is a Golgi-localized Type II transmembrane protein

Siddiqui MF, Li J, Wang S, Zhang H, Qin C. Lu Y: FAM20A is a Golgi-localized Type II transmembrane protein. Scientific Reports, 14: 6518. 2024

2023 Constitutive expression of spliced X-box binding protein 1 inhibits dentin formation in mice

Xu X, Li J, Zhang H, Wang S, Qin C, Lu Y: Constitutive expression of spliced X-box binding protein 1 inhibits dentin formation in mice. Front Physiol.  14: 1319954. 2023

2023 Intracranial calcification in Fam20c-deficient mice recapitulates human Raine syndrome

Zhang H, Lu Y, Kramer P, Benson MD, Cheng YL, Qin C: Intracranial calcification in Fam20c-deficient mice recapitulates human Raine syndrome. Neurosci Lett. 802:137176. 2023

2022 Long-acting PFI-2 small molecule release and multilayer scaffold design achieve extensive new formation of complex periodontal tissues with unprecedented fidelity

Lyu H, Zhou X, Qian Y, Liu X, Gopinathan G, Pandya M, Qin C, Luan X, Diekwisch T: “Long-acting PFI-2 small molecule release and multilayer scaffold design achieve extensive new formation of complex periodontal tissues with unprecedented fidelity.” Biomaterials. 290: 121819. 2022

2022 Adenomatoid Odontogenic Tumor: Evidence for a Mixed Odontogenic Tumor

Barnts K, Feng JQ, Qin C, Zhang H, Cheng YL: Adenomatoid Odontogenic Tumor: Evidence for a Mixed Odontogenic Tumor. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 133: 675–683.  2022

2022 FAM20C plays a critical role in the development of mouse vertebra

Huang Y, Chen H, Zhang H, Lu Y, Qin C: FAM20C plays a critical role in the development of mouse vertebra. Spine J. 22: 337–348, 2022

2021 Enamel defects associated with dentin sialophosphoprotein mutation in mice

Liang T, Xu Q, Zhang H, Wang S, Diekwisch T, Qin C, Lu Y: Enamel defects associated with dentin sialophosphoprotein mutation in mice. Front Physiol. 12: 724098, 2021

2021 High phosphate diet improved the formation of dentin in Fam20c-deficient mice

Zhang H, Xu Q, Lu Y, Qin C: High phosphate diet improved the formation of dentin in Fam20c-deficient mice. Eur J Oral Sci. 129:e12795, 2021

2021 Constitutive Expression of Spliced XBP1 Causes Perinatal Lethality in Mice

Xu Q, Zhang H, Wang S, Qin C, Lu Y: Constitutive Expression of Spliced XBP1 Causes Perinatal Lethality in Mice. Genesis. 59:e23420, 2021

2020 Noggin inhibition of mouse dentinogenesis

10.Jani P, Zhang H, Benson D, Qin C: Noggin inhibition of mouse dentinogenesis. J Oral Biosci; 62:72-79, 2020.

2020 High phosphate diet improved the skeletal development of Fam20C-deficient mice

Zhang H, Li l, Lu Y, Qin C: High phosphate diet improved the skeletal development of Fam20C-deficient mice. Cells Tissues Organs. 208:25-36, 2020.

2019 FAM20A is essential for amelogenesis, but is dispensable for dentinogenesis

Li L, Saiyin W, Zhang H, Wang S, Xu Q, Qin C, Lu Y: FAM20A is essential for amelogenesis, but is dispensable for dentinogenesis. J Mol Histol. 50:581-591, 2019

2019 Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF-β and MAPK signaling pathways

Saiyin W, Li L, Zhang H, Lu Y, Qin C: Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF-β and MAPK signaling pathways. Biochim Biophys Acta Mol Basis Dis. 1865:165555. 2019

2019 Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice

Miao N, Zhan Y, Xu Y, Yuan H, Qin C, Lin F, Xie X, Mu S, Yuan M, Mu H, Guo S, Li Y, Zhang B: Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice. Int J Mol Med. 43:2103-2117, 2019

2019 Liang T, Zhang H, Xu Q, Wang S, Qin C, Lu Y: Mutant Dentin Sialophosphoprotein Causes Dentinogenesis Imperfecta. J Dent Res. 98:912-919, 2019

Liang T, Zhang H, Xu Q, Wang S, Qin C, Lu Y. Mutant Dentin Sialophosphoprotein Causes Dentinogenesis Imperfecta. J Dent Res. 2019;98:912-919.

2018 Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects

Liu X, Li N, Zhang H, Liu J, Zhou N, Ran C, Chen X, Lu Y, Wang X, Qin C, Xiao J, Liu C: Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects. Eur J Oral Sci. 126:433-436, 2018

2018 Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice

Zhang H, Xie X, Liu P, Liang T, Lu Y, Qin C: Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice. PLoS One 13:e0195854, 2018

2018 Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells

Liu C, Zhou N, Wang Y, Zhang H, Jani P, Wang X, Lu Y, Li N, Xiao J, Qin C: Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells. Exp Cell Res. 363:188-195, 2018

2018 The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis

Jani P,  Liu C, Zhang H, Younes K, Benson MD, Qin C: The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis. Arch Oral Biol. 90:33-39, 2018

2018 FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner

Liu C, Zhang H, Jani P, Wang X, Lu Y, Li N, Xiao J, Qin C: FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner. J Cell Physiol. 233:3476-3486, 2018

2018 Probing the influence of SIBLING proteins on collagen-I fibrillogenesis and denaturation

Jiang C, Zurick K, Qin C, Bernards MT: Probing the influence of SIBLING proteins on collagen-I fibrillogenesis and denaturation. Connect Tissue Res. 59:274-286, 2018

2017 The importance of a potential phosphorylation site in enamelin on enamel formation

Yan W, Ma P, Tian Y, Wang J, Qin C, Feng J, Wang X: The importance of a potential phosphorylation site in enamelin on enamel formation. Int J Oral Sci. 9:e4, 2017

2017 Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice

Zhang H, Jani P, Liang T, Lu Y, Qin C: Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of Molecular Histology. 48:83-98, 2017

2017 Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia

Liu P, Ma S, Zhang H, Liu C, Lu Y, Chen L, Qin C: Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia. Sci Rep. 7:3590, 2017

2017 Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice

Arnold P, Koopmann L, Peters F, Birkenfeld F, Goff SV, Damm T, Qin C, Moali C, Lucius R, Becker-Pauly C: Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice. Cell Tissue Res. Cell and Tissue Research. 367:351-358, 2017

2016 Transgenic expression of dentin phosphoprotein inhibits skeletal development

Zhang H, Liu P, Wang S, Liu C, Jani P, Lu Y, Qin C: Transgenic expression of dentin phosphoprotein inhibits skeletal development. Eur J Histochem. 60:2587, 2016

2016 Loss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowth

Li L, Liu P, Xie X, Ma S, Liu C, Chen L, Qin C: Loss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowth. Int J Oral Sci. 8:98-109, 2016

2016 Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice

Jani PH, Gibson MP, Liu C, Zhang H, Wang X, Lu Y, Qin C: Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix Biol. 52-54:95-112, 2016

2016 Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression

Xie X, Liu C, Zhang H, Jani PH, Lu Y, Wang X, Zhang B, Qin C: Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression. Sci Rep. 6:25364, 2016

2016 Tanshinone IIA treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A

Ma S, Liu W, Liu P, Liu J, Chen L, Qin C: Tanshinone IIA treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A. J Periodont Res. 51:567-576, 2016

2016 Accelerated Enamel Mineralization in Dspp mutant mice

Verdelis K, Szabo-Rogers H, Xu Y, Chong R, Kang R, Cusack B, Jani P, Boskey A, Qin C, Beniash E:  Accelerated Enamel Mineralization in Dspp mutant mice. Matrix Biol. 52-54:246-259, 2016

2016 Repair of dentin defects from DSPP knockout mice by PILP mineralization

Nrrohman H, Saeki K, Carneiro K, Chien Y, Djomehri S, Ho S, Qin C Marshall S, Gower L, Marshall G, Habelitz S: Repair of dentin defects from DSPP knockout mice by PILP mineralization. J Mater Res. 31:321-327, 2016.

2016 Inactivation of Fam20B in joint cartilage leads to chondrosarcoma and postnatal ossification defects

Ma P, Yan W, Tian Y, Wang J, Feng JQ, Qin C, Cheng YS, Wang X. Inactivation of Fam20B in joint cartilage leads to chondrosarcoma and postnatal ossification defects. Sci Rep. 6:29814, 2016

2016 The LPV Motif is Essential for the Efficient Export of Secretory DMP1 from the Endoplasmic Reticulum

Liang T, Meng T, Wang S, Qin C, Lu Y: The LPV Motif is Essential for the Efficient Export of Secretory DMP1 from the Endoplasmic Reticulum. J Cell Physiol. 231:1468-1475, 2016

2015 Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors

Tian Y, Ma P, Liu C, Yang X, Crawford DM, Yan W, Bai D, Qin C, Wang X: Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors.  Eur J Oral Sci. 123:396-402, 2015

2015 Twist1 is Essential for Tooth Morphogenesis and Odontoblast Differentiation

Meng T, Huang Y, Wang S, Zhang H, Dechow PC, Wang X, Qin C, Shi B, D'Souza RN, Lu Y: Twist1 is Essential for Tooth Morphogenesis and Odontoblast Differentiation. J Biol Chem. 290:29593-29602, 2015

2015 Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves

Wu W, Gu S, Sun C, He W, Xie X, Li X, Ye W, Qin C, Chen Y, Xiao J, Liu C: Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves. PLoS One.10:e0136951, 2015

2015 An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage

Fujikawa K, Yokohama-Tamaki T, Morita T, Baba O, Qin C, Shibata S: An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.  Eur J Histochem. 59:e2553, 2015

2015 Letter to the Editor, "Osterix Regulates Tooth Root Formation in a Site-specific Manner"

Feng J, Zhang H, Qin C: Letter to the Editor, "Osterix Regulates Tooth Root Formation in a Site-specific Manner". J Dent Res.  94:1326, 2015

2015 Dspp-independent effects of transgenic Trps1 overexpression on dentin formation

Mobley C, Kuzynski M, Zhang H, Jani P, Qin C, Napierala D: Dspp-independent effects of transgenic Trps1 overexpression on dentin formation. J Dent Res. 94:1128-1134, 2015

2015 The immortalized mouse floxed Fam20c dental papillar mesenchymal and osteoblast cell lines retain their primary genotypes and phenotypes

Liu C, Wang X, Zhang H, Xie X, Liu P, Liu Y, Jani PH, Lu Y, Chen S, Qin C: The immortalized mouse floxed Fam20c dental papillar mesenchymal and osteoblast cell lines retain their primary genotypes and phenotypes. Journal of Cellular Physiology. 230:2581-2587, 2015

2015 Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model

Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, Qin C, Ke H, Liu M, Feng JQ: Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model. FASEB J. 29:2702-2711, 2015

2015 Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice

Du E, Wang X, Yang W, Kaback D, Yee S, Qin C, George A, Hao J: Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice. International Journal of Oral Science. 7:89-94, 2015

2015 Essential role of Osterix for tooth root but not crown dentin formation

Zhang H, Jiang Y, Sunita PH, Liu Y, Qin C, Feng JQ: Essential role of Osterix for tooth root but not crown dentin formation. J Bone Miner Res. 30:742-746, 2015

2015 The specific role of FAM20C in dentinogenesis

Wang X, Wang J, Liu Y, Yuan B, Ruest LB, Feng JQ, Qin C: The specific role of FAM20C in dentinogenesis. J Dent Res. 94:330-336, 2015

2014 Inactivation of FAM20C in cells expressing Type I collagen causes periodontal disease in mice

Liu P, Zhang H, Liu C, Wang X, Chen L, Qin C: Inactivation of FAM20C in cells expressing Type I collagen causes periodontal disease in mice. PLoS One. 9:e114396, 2014

2014 Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice

Gibson MP, Jani P, Wang X, Lu Y, Qin C: Overexpressing the NH₂-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice. Journal of Oral Biosciences. 56:143-148, 2014

2014 Cyclosporine A Inhibits Apoptosis of Rat Gingival Epithelium

Ma S, Liu P, Li Y, Hou L, Chen L, Qin C: Cyclosporine A Inhibits Apoptosis of Rat Gingival Epithelium.  J Periodontol. 85:1126-1134, 2014

2014 Twist1- and Twist2-haploinsufficiency results in reduced bone formation

Huang Y, Meng T, Wang S, Zhang H, Mues G, Qin C, Feng JQ, D'Souza RN, Lu Y: Twist1- and Twist2-haploinsufficiency results in reduced bone formation. PLoS One. 9:e99331, 2014

2014 Expression of small integrin-binding ligand N-linked glycoproteins (SIBLINGs) in the reparative dentin of rat molars

Xie X, Ma S, Li C, Liu P, Wang H, Chen L, Qin C: Expression of small integrin-binding ligand N-linked glycoproteins (SIBLINGs) in the reparative dentin of rat molars. Dental Traumatology 30:285-295, 2014

2014 Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice

Wang X, Wang J, Yuan B, Lu Y, Feng JQ, Qin C: Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice. Connect Tissue Res. 55:299-303, 2014

2014 Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype

Lin S, Zhang Q, Cao Z, Lu Y, Zhang H, Yan K, Liu Y, McKee MD, Qin C, Chen Z, Feng JQ: Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. J Biol Chem. 289:21533-21543, 2014

2013 The specific role of FAM20C in amelogenesis

Wang X, Jung J, Liu Y, Yuan B, Lu Y, Feng J, Qin C: The specific role of FAM20C in amelogenesis. J Dent Res. 92:995-999, 2013

2013 Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage

Liu Q, Gibson MP, Sun H, Qin C: Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage. J Histochem Cytochem. 61:749-758, 2013

2013 Failure to process dentin sialophosphoprotein (DSPP) into fragments leads to periodontal defects in mice

Gibson MP, Jani P, Liu Y, Wang X, Lu Y, Feng J, Qin C: Failure to process dentin sialophosphoprotein (DSPP) into fragments leads to periodontal defects in mice. Eur J Oral Sci. 121:545-550, 2013

2013 Loss of DSPP leads to periodontal disease in mice

Gibson MP, Zhu Q, Liu Q, D’Souza R, Feng J, Qin C: Loss of DSPP leads to periodontal disease in mice. J. Periodontal Res. 48:221-227, 2013

2013 Role of the NH2-terminal fragment of dentin sialophosphoprotein in dentinogenesis

Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng JQ, Qin C: Role of the NH₂-terminal fragment of dentin sialophosphoprotein in dentinogenesis. Eur J Oral Sci. 121:76-85, 2013

2013 The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis

Gibson MP, Zhu Q, Wang S, Liu Q, Liu Y, Wang X, Yuan B, Ruest LB, Feng JQ, D'Souza RN, Qin C (co-corresponding author), Lu Y: The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. J Biol Chem. 288:7204-7214, 2013

2013 Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration

Sun Y, Jiang Y, Liu Q, Gao T, Feng JQ, Dechow P, D'Souza RN, Qin C, Liu X: Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration. Tissue Eng Part A. 19:1754-1763, 2013

2013 An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses

Shibata S, Sakamoto Y, Baba O, Qin C, Murakami G, Cho BH (2013): An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses. Eur J Histochem. 57:e39, 2013

2013 Differential expression and localization of dentin matrix protein 1 (DMP1) fragments in mouse submandibular glands

Li C, Xie X, Wang X, Sun Y, Liu P, Chen L, Qin C: Differential expression and localization of dentin matrix protein 1 (DMP1) fragments in mouse submandibular glands. J Mol Histol. 44:231-239, 2013

2013 Mineralization induction effects of osteopontin, bone sialoprotein, and dentin phosphoprotein on a biomimetic collagen substrate

Zurick KM, Qin C, Bernards MT: Mineralization induction effects of osteopontin, bone sialoprotein, and dentin phosphoprotein on a biomimetic collagen substrate. J Biomed Mater Res A. 101:1571-1581, 2013

2012 Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis

Zhu Q, Gibson MP, Liu Q, Liu Y, Lu Y, Wang X, Feng JQ, Qin C: Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis. J Biol Chem.  287:30426-30435, 2012

2012 FAM20C plays an essential role in the formation of murine teeth

Wang X, Wang S, Lu Y, Gibson MP, Liu Y, Yuan B, Feng JQ, Qin C: FAM20C plays an essential role in the formation of murine teeth. J Biol Chem. 287:35934-35942, 2012

2012 Nuclear localization of DMP1 proteins suggests a role in intracellular signaling

Siyam A, Wang S, Qin C, Mues G, Stevens R, D'Souza R, Lu Y: Nuclear localization of DMP1 proteins suggests a role in intracellular signaling. Biochem Biophys Res Commun.   , 2012

2012 Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation

Rangiani A, Cao ZG, Liu Y, Voisey Rodgers A, Jiang Y, Qin C, Feng JQ: Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation. Int J Oral Sci. 4:189-195, 2012

2012 Adhesion of MC3T3-E1 cells bound to dentin phosphoprotein specifically bound to collagen type I

Zurick KM, Qin C, Bernards MT. Adhesion of MC3T3-E1 cells bound to dentin phosphoprotein specifically bound to collagen type I. J Biomed Mater Res A. 100: 2492-2498, 2012

2012 Protective roles of DMP1 in high phosphate homeostasis

Rangiani A, Cao Z, Sun Y, Lu Y, Gao T, Yuan B, Rodgers A, Qin C, M Kuro-o M, Feng JQ: Protective roles of DMP1 in high phosphate homeostasis. PLoS One. 7: e42329, 2012

2012 Partial blocking of mouse DSPP processing by substitution of Gly451-Asp452 bond suggests the presence of secondary cleavage site(s)

Zhu Q, Prasad M, Kong H, Lu Y, Sun Y, Wang X, Yamoah A, Feng JQ, Qin C: Partial blocking of mouse DSPP processing by substitution of Gly⁴⁵¹-Asp⁴⁵² bond suggests the presence of secondary cleavage site(s). Connect Tissue Res. 53: 307-312, 2012

2012 Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype of Colla1-Trps1 transgenic mice

Napierala D, Sun Y, Maciejewska I, Bertin TK, Dawson B, D'Souza R, Qin C, Lee B: Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype of Colla1-Trps1 transgenic mice. J Bone Miner Res. 27:1735-1745, 2012

2012 Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice

Wang X, Wang S, Li C, Gao T, Liu Y, Rangiani A, Sun Y, Hao J, George A, Lu Y, Groppe J, Yuan B, Feng JQ, Qin C: Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS Genet. 8: e1002708, 2012

2012 Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

Qin Q, Xu Y, He T, Qin C, Xu J: Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Res. 22:90-106, 2012

2011 Expression of dentin sialophosphoprotein in non-mineralized tissues

Prasad M, Zhu Q, Sun Y, Wang X, Kulkarni A, Boskey A, Feng JQ, Qin C: Expression of dentin sialophosphoprotein in non-mineralized tissues. J Histochem Cytochem. 59:1009-21, 2011

2011 Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis

Sun Y, Chen L, Ma S, Zhou J, Feng JQ, Qin C: Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis. Cells Tissues Organs. 194:199-204, 2011

2011 DMP1 Processing is Essential to Dentin and Jaw Formation

Sun Y, Lu Y, Chen L, Gao T, D'Souza R, Feng JQ, Qin C. DMP1 Processing is Essential to Dentin and Jaw Formation. J Dent Res. 90:619-624, 2011

2011 Unique roles of phosphorus in endochondral bone formation and osteocyte maturation

Zhang R, Lu Y, Ye L, Yuan B, Yu S, Qin C, Xie Y, Gao T, Drezner MK, Bonewald LF, Feng JQ: Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. J Bone Miner Res. 26:1047-1056, 2011

2011 Single-nucleotide polymorphisms (SNPs) of the IRF6 and TFAP2A in non-syndromic cleft lip with or without cleft palate (NSCLP) in a northern Chinese population

Shi J, Song T, Jiao X, Qin C, Zhou J. Single-nucleotide polymorphisms (SNPs) of the IRF6 and TFAP2A in non-syndromic cleft lip with or without cleft palate (NSCLP) in a northern Chinese population. Biochem Biophys Res Commun. 410:732-736, 2011

2011 A novel role of periostin in postnatal tooth formation and mineralization

Ma D, Zhang R, Sun Y, Rios HF, Haruyama N, Han X, Kulkarni AB, Qin C, Feng JQ:  A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem. 286:4302-4309, 2011

2011 The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment

Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF, Feng JQ: The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. J Bone Miner Res.  26:331-340, 2011

2010 Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis

Sun Y, Prasad M, Gao T, Wang X, Zhu Q, D'Souza R, Feng JQ, Qin C: Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. J Biol Chem. 285:31713-31722, 2010

2010 DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype

Jiang B, Cao Z, Lu Y, Janik C, Lauziere S, Xie Y, Poliard A, Qin C, Ward LM, Feng JQ: DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. J Bone Miner Res. 25:2155-2164, 2010

2010 Glycosaminoglycan chain of dentin sialoprotein proteoglycan

Zhu Q, Sun Y, Prasad M, Wang X, Yamoah AK, Li Y, Feng J, Qin C: Glycosaminoglycan chain of dentin sialoprotein proteoglycan. J Dent Res. 89:808-812, 2010

2010 Key proteolytic cleavage site and full-length form of DSPP

Sun Y, Lu Y, Chen S, Prasad M, Wang X, Zhu Q, Zhang J, Ball H, Feng J, Butler WT, Qin C: Key proteolytic cleavage site and full-length form of DSPP. J Dent Res.  89:498-503, 2010

2010 Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the articular cartilage of the rat femoral head

Sun Y, Ma S, Zhou J, Yamoah AK, Feng JQ, Hinton RJ, Qin C: Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the articular cartilage of the rat femoral head. J Histochem Cytochem. 58:1033-1043, 2010

2010 Expression of FAM20C in the osteogenesis and odontogenesis of mouse

Wang X, Hao J, Xie Y, Sun Y, Hernandez B, Yamoah AK, Prasad M, Zhu Q, Feng JQ, Qin C: Expression of FAM20C in the osteogenesis and odontogenesis of mouse. J Histochem Cytochem. 58:957-967, 2010

2010 Expression and distribution of SIBLING proteins in the predentin/dentin and mandible of hyp mice

Zhang B, Sun Y, Chen L, Guan C, Guo L, Qin C: Expression and distribution of SIBLING proteins in the predentin/dentin and mandible of hyp mice. Oral Dis. 16:453-464, 2010

2010 Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible

Sun Y, Gandhi V, Prasad M, Yu W, Wang X, Zhu Q, Feng JQ, Hinton RJ, Qin C: Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible. Int J Oral Maxillofac Surg. 39:272-281, 2010

2010 Dentin sialophosphoprotein in biomineralization

Prasad M, Butler WT, Qin C: Dentin sialophosphoprotein in biomineralization. Connect Tissue Res. 51:404-417, 2010

2010 Different forms of DMP1 play distinct roles in mineralization

Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT, Boskey AL: Different forms of DMP1 play distinct roles in mineralization. J Dent Res. 2010, 89:355-359, 2010

2010 Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus

Lv K, Huang H, Lu Y, Qin C, Li Z, Feng JQ: Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus. Int J Biol Sci. 6:537-545, 2010

2010 CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population

Shi J, Jiao X, Song T, Zhang B, Qin C, Cao F: CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population. Eur J Oral Sci. 118:430-433, 2010

2009 The NH2-terminal and COOH-terminal Fragments of Dentin Matrix Protein 1 (DMP1) Localize Differently in the Compartments of Dentin and Growth Plate of Bone

Maciejewska I, Cowan C, Svoboda K, Butler WT, D'Souza R, Qin C: The NH₂-terminal and COOH-terminal Fragments of Dentin Matrix Protein 1 (DMP1) Localize Differently in the Compartments of Dentin and Growth Plate of Bone. J Histochem Cytochem. 57:155-166, 2009

2009 FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors

Lin Y, Cheng YS, Qin C, Lin C, D'Souza R, Wang F: FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors. Dev Dyn. 238:324-330, 2009

2009 Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells

Maciejewska I, Qin D, Huang B, Sun Y, Mues G, Svoboda K, Bonewald LF, Butler WT, Feng J, Qin C: Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells. Cells Tissues Organs. 189:186-191, 2009

2009 Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues

Peng T, Huang B, Sun Y, Lu Y, Bonewald LF, Chen S, Butler WT, Feng J, D’Souza RN, Qin C: Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells Tissues Organs. 189:192-197, 2009

2009 Studies of the DMP1 57-kDa Functional Domain both in vivo and in vitro

Lu Y, Qin C, Xie Y, Bonewald LF, Feng JQ: Studies of the DMP1 57-kDa Functional Domain both in vivo and in vitro. Cells Tissues Organs. 189:175-185, 2009

2008 Expression and process of small integrin-binding ligand N-linked glycoproteins in mouse odontoblasts

Chen S, Chen L, Jahangiri A, Chen B, Wu Y, Chuang H, Qin C, MacDougall M:  Expression and process of small integrin-binding ligand N-linked glycoproteins in mouse odontoblasts. Arch Oral Biol, 53:879-889, 2008

2008 Full-length dentin matrix protein 1 in dentin and bone

Huang B, Maciejewska I, Sun Y,  Peng T, Qin D, Bonewald L, Butler WT, Feng J, Qin C:  Full-length dentin matrix protein 1 in dentin and bone. Calcif Tissue Int. 82: 401-410, 2008

2008 MC3T3-E1 cell adhesion to hydroxyapatite with adsorbed bone sialoprotein, bone osteopontin, and bovine serum albumin

Bernards MT, Qin C (co-corresponding author), Jiang S (co-corresponding author): MC3T3-E1 cell adhesion to hydroxyapatite with adsorbed bone sialoprotein, bone osteopontin, and bovine serum albumin. Colloids Surf B Biointerfaces. 64: 236-247, 2008

2008 Distribution of SIBLING proteins in the organic and inorganic phases of rat dentin and bone

Huang B, Sun Y, Maciejewska I, Qin D, Peng T, Mclntyre B, Wygant J,  Butler WT, Qin C:  Distribution of SIBLING proteins in the organic and inorganic phases of rat dentin and bone.  Eur J Oral Sci. 116: 104-112, 2008

2008 Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an IL-1-mediated autocrine mechanism

Yao Z, Xiang L, Qin C, Schwarz EM, Boyce BF: Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an IL-1-mediated autocrine mechanism. J Biol Chem. 283: 9917-9924, 2008

2008 A comparison of the MC3T3-E1 adhesion properties of bone sialoprotein and bone osteopontin specifically bound to collagen I

Bernards MT, Qin C, Ratner BD, Jiang S (co-corresponding author): A comparison of the MC3T3-E1 adhesion properties of bone sialoprotein and bone osteopontin specifically bound to collagen I.  J Biomed Mater Res A. 86:779-787, 2008

2008 An immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice

Shibata S, Baba O, Oda T, Tamaki T,  Qin C, Butler T, Sakakura Y, Takano Y: An immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice. Arch Oral Biol. 53:220-230. 2008

2007 Dentin Matrix Protein 1 (DMP1): New and Important Roles for Biomineralization and Phosphate Homeostasis

Qin C, D’Souza R, Feng J: Dentin Matrix Protein 1 (DMP1): New and Important Roles for Biomineralization and Phosphate Homeostasis. J Dent Res. 86: 1134-1141, 2007

2007 Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite

Gajjeraman S, Narayanan K, Hao J, Qin C, George A:  Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. J Biol Chem. 282:1193-1204, 2007

2007 Controlling the orientation of bone osteopontin via its specific binding with collagen I to modulate osteoblast adhesion

Liu L, Qin C, Butler WT, Ratner BD, Jiang S: Controlling the orientation of bone osteopontin via its specific binding with collagen I to modulate osteoblast adhesion. J Biomed Mater Res A. 80:102-110, 2007

2006 A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment

Qin C, Huang B, Wygant JN, McIntyre BW, McDonald CH, Cook RG, Butler WT:  A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH₂-terminal fragment. J Biol Chem. 281:8034-8040, 2006

2006 Immunohistochemical study of small integrin-binding ligand, N-linked glycoproteins in reactionary dentin of rat molars at different ages

Moses KD, Butler WT, Qin C: Immunohistochemical study of small integrin-binding ligand, N-linked glycoproteins in reactionary dentin of rat molars at different ages. Eur J Oral Sci. 114:216-222, 2006

2005 Spatially and temporally controlled biomineralization is facilitated by interaction between self-assembled dentin matrix protein 1 and calcium phosphate nuclei in solution

He G, Gajjeraman S, Schultz D, Cookson D, Qin C, Butler WT, Hao J, George A: Spatially and temporally controlled biomineralization is facilitated by interaction between self-assembled dentin matrix protein 1 and calcium phosphate nuclei in solution. Biochemistry. 44:16140-16148, 2005

2005 Dentin Matrix Protein 1 (DMP1) and Dentin Sialophosphoprotein (DSPP) Share Unique Properties Including Tissue Localization, Proteolytic Processing, and High Molecular Weight Forms

Qin C, Baba O, Brunn JC, McKee MD, Bonewald L, Butler WT:  Dentin Matrix Protein 1 (DMP1) and Dentin Sialophosphoprotein (DSPP) Share Unique Properties Including Tissue Localization, Proteolytic Processing, and High Molecular Weight Forms. In: Sodek J, Landis W, ed. Proceedings of the 8th ICCBMT. Banff, Alberta, Canada: University of Toronto Press, 2005; pp 174-177, 2005

2005 Immunolocalization of dentin matrix protein 1 (DMP1) fragments in developing rat molar

Baba O, Qin C, Brunn JC, Bonewald L, Terashima T, Butler WT:  Immunolocalization of dentin matrix protein 1 (DMP1) fragments in developing rat molar. In: Sodek J, Landis W, ed. Proceedings of the 8th ICCBMT. Banff, Alberta, Canada: University of Toronto Press, pp 143-146, 2005

2005 High throughput screening of proteins involved in biomineralization suggests role for α2-HS glycoprotein

Boskey AL, Spevak L, Fujimoto Y, Silverman L, Qin C, Brunn JC, Butler WT:  High throughput screening of proteins involved in biomineralization suggests role for α₂-HS glycoprotein. In: Sodek J, Landis W, ed. Proceedings of the 8th ICCBMT. Banff, Alberta, Canada: University of Toronto Press, pp 224-226, 2005

2005 Importance of phosphorylation for osteopontin regulation of biomineralization

Gericke A, Qin C, Spevak L, Fujimoto Y, Butler WT, Sorensen ES, Boskey AL: Importance of  phosphorylation for osteopontin regulation of biomineralization. Calcif Tissue Int. 77:45-54, 2005

2005 Developmental analysis and computer modelling of bioengineered teeth

Young CS, Kim SW, Qin C, Baba O, Butler WT, Taylor RR, Vacanti JP, Bartlett JD, Yelick PC: Developmental analysis and computer modelling of bioengineered teeth. Arch Oral Biol. 50:259-265, 2005

2004 Posttranslational modifications of SIBLING proteins and their roles in osteogenesis and dentinogenesis

Qin C, Baba O and Butler WT: Posttranslational modifications of SIBLING proteins and their roles in osteogenesis and dentinogenesis. Crit Rev Oral Biol Med. 15:126-136, 2004 

2004 Co-localization of dentin matrix protein 1 (DMP1) and dentin sialoprotein (DSP) at late stages of rat molar development

Baba O, Qin C*, Brunn JC, Wygant JN, McIntyre BW, Butler WT: Co-localization of dentin matrix protein 1 (DMP1) and dentin sialoprotein (DSP) at late stages of rat molar development. Matrix Biol. 23:371-379, 2004 (*corresponding author)

2004 Detection of dentin sialoprotein (DSP) in periodontium

Baba O, Qin C, Brunn JC, Jones JE, Wygant JN, McIntyre BW, Butler WT: Detection of dentin sialoprotein (DSP) in periodontium. Eur J Oral Sci. 112:163-170, 2004

2004 Dentin matrix protein-1: In vitro effects on hydroxyapatite formation provide insights into in vivo functions

Tartaix PH, Doulaverakis M, George A, Fisher LW, Butler WT, Qin C, Salih E, Tan M, Fujimoto Y, Spevak L, Boskey AL: Dentin matrix protein-1: In vitro effects on hydroxyapatite formation provide insights into in vivo functions. J Biol Chem. 279:18115-18120, 2004

2003 Proteolytic processing and cleavage sites

Proteolytic processing and cleavage sites. J Biol Chem. 278:34700-34708, 2003

2003 Dentin sialoprotein isoforms: detection and characterization of a high molecular weight dentin sialoprotein (HMW-DSP)

Qin C, Brunn JC, Baba O, Wygant JN, McIntyre BW, Butler WT: Dentin sialoprotein isoforms: detection and characterization of a high molecular weight dentin sialoprotein (HMW-DSP). Eur J Oral Sci. 111:235-242, 2003

2003 Dentin sialoprotein in bone and dentin sialophosphoprotein gene expressed by osteoblasts

Qin C, Brunn JC, Cadena E, Ridall A, Butler WT: Dentin sialoprotein in bone and dentin sialophosphoprotein gene expressed by osteoblasts. Conn Tissue Res. 44:179-183, 2003

2003 Extracellular matrix (ECM) proteins: Comparison to bone and contribution to dynamics of dentinogenesis

Butler WT, Brunn JC, Qin C: Extracellular matrix (ECM) proteins: Comparison to bone and contribution to dynamics of dentinogenesis. Conn Tissue Res. 44:171-178, 2003

2002 The expression of dentin sialophosphoprotein gene in bone

Qin C, Brunn JC, Cadena E, Ridall A, Tsujigiwa H, Nagatsuka H, Nagai N and Butler WT: The expression of dentin sialophosphoprotein gene in bone. J Dent Res. 81:392-394, 2002

2002 Osteopontin post-translational modifications, possibly phosphorylation is required for in vitro bone resorption but not osteoclast adhesion

Razzouk S, Brunn JC, Qin C, Tye C, Goldburg HA, Butler WT: Osteopontin post-translational modifications, possibly, phosphorylation is required for in vitro bone resorption but not osteoclast adhesion. Bone. 30:40-47, 2002

2002 Extracellular matrix (ECM) proteins and the dynamics of dentin formation

Butler WT, Brunn JC, Qin C, McKee MD: Extracellular matrix (ECM) proteins and the dynamics of dentin formation. Conn Tissue Res. 43:301-307, 2002

2001 Identification and characterization of the carboxy-terminal region of rat dentin sialoprotein (DSP)

Qin C, Cook RG, Orkiszewski RS, Butler WT: Identification and characterization of the corboxy-terminal region of rat dentin sialoprotein (DSP). J Biol Chem 276:904-909, 2001

2001 A comparative study of sialic acid-rich proteins in rat bone and dentin

Qin C, Brunn JC, Jones J, George A, Ramachandran A, Gorski JP, Butler WT: A comparative study of sialic acid-rich proteins in rat bone and dentin. Eur J Oral Sci. 109:133-141, 2001

1999 Age effects on ectopic bone formation induced by purified bone morphogenetic protein

Nagai N, Qin C, Nagatsuka H, Inoue M, Ishiwari Y: Age effects on ectopic bone formation induced by purified bone morphogenetic protein. Int J Oral Maxillofac Surg 28:143-150, 1999

1997 Aging and ectopic bone formation induced by partially purified bone morphogenetic protein

Qin C, Murata M, Nagatsuka H, Inoue M, Nagai N: Aging and ectopic bone formation induced by partially purified bone morphogenetic protein. Jpn J Oral Biol. 39:352-362, 1997

1997 Aging and ectopic bone formation induced by partially purified bone morphogenetic protein: Blood vessel ingrowth and localization of type I collagen and osteocalcin assessed by immunohistochemistry

Qin C, Nakano K, Ishiwari Y, Nagai N:  Aging and ectopic bone formation induced by partially purified bone morphogenetic protein: Blood vessel ingrowth and localization of type I collagen and osteocalcin assessed by immunohistochemistry.  J Hard Tissue Biol. 6:95-104, 1997

1997 Morphological and immunohistochemical study of ectopic bone formation induced by crude BMP in 4-week and 6-month old rats

Qin C, Murata M, Nagatsuka H, Kuroda K, Nagai N: Morphological and immunohistochemical study of ectopic bone formation induced by crude BMP in 4-week and 6-month old rats.  J Jpn Soc Oral Implant.  10:288-295, 1997.

1995 Comparative study of heterotopic bone formation induced by BMP in adult and young rats

Qin C, Murata M, Ionue M, Nagatsuka H, Akagi T, Nagai N:  Comparative study of heterotopic bone formation induced by BMP in adult and young rats.  Proceedings of the Fourth International Congress on Oral Cancer, Gifu, Japan pp 229-232.  1995.

1994 Destructive process of salivary gland parenchyma and development of epimyoepithelial islands assessed by immunohistochemistry

Qin C, Pan YL, Hashimura J, Takai Y, Yamada T, Mori M: Destructive process of salivary gland parenchyma and development of epimyoepithelial islands assessed by immunohistochemistry. Arch Anat Cytol Pathol. 42:16-25, 1994

1994 Histogenesis and possible mechanism of chondroid changes in mixed tumor of the skin

Mori M, Shrestha P, Sakamoto F, Yang LJ, Qin C, Tsujimura T: Histogenesis and possible mechanism of chondroid changes in mixed tumor of the skin: Immunohistochemical evaluation of bone morphogenetic protein, glycosaminoglycans, keratin, vimentin and neuronal marker. Arch Dermatol Res. 286:285-292, 1994

1994 Clear cell carcinomas of salivary glands: Immunohistochemical evaluation of clear tumor cells

Shrestha P, Yang LJ, Liu BL, Namba M, Qin C, Isono K, Tsukitani K, Mori M: Clear cell carcinomas of salivary glands: Immunohistochemical evaluation of clear tumor cells. Anticancer Res. 14:825-836, 1994

1994 Comparison of proliferating cell nuclear antigen index in benign and malignant salivary pleomorphic adenoma

Yang LJ, Liu BL, Qin C, Hashimura K, Yamada T, Sumitomo S, Mori M: Comparison of proliferating cell nuclear antigen index in benign and malignant salivary pleomorphic adenoma. Eur J Cancer B Oral Oncol. 30B:50-60, 1994

1993 Immunoreactivity of proliferating cell nuclear antigen in salivary gland tumors: An assessment of growth potential

Yang LJ, Hashimura K, Qin C, Shrestha P, Sumitomo S, Mori M: Immunoreactivity of proliferating cell nuclear antigen in salivary gland tumors: An assessment of growth potential. Virchows Arch A Pathol Anat Histopathol. 422:481-486, 1993