Texas A&M University College of Dentistry

Larry L. Bellinger, PhD

Adjunct Professor Regents Professor Emeritus Former Associate Dean for Research & Graduate Studies Department of Biomedical Sciences | College of Dentistry
Contact Groups and Affiliations

Biography

Career History

  • Regents Professor Emeritus, Department of Biomedical Sciences, Texas A&M University College of Dentistry (2020 to Present)
  • Adjunct Professor, Department of Biomedical Sciences, Texas A&M University College of Dentistry (2020 to Present)
  • Associate Dean for Research and Graduate Studies, Texas A&M University College of Dentistry (2004-2020)
  • Regents Professor,Department of Biomedical Sciences, Texas A&M College of Dentistry (2003-2020)
  • Professor, Department of Biomedical Sciences, Texas A&M University College of Dentistry (1985-2002)
  • Associate Professor, Department of Physiology, College of Dentistry (1979-1985)
  • Associate Professor, Baylor University Graduate School, Dallas (1979-1985)
  • Assistant Professor,Department of Physiology, College of Dentistry (1976-1979)
  • Assistant Professor,Baylor University Graduate School, Dallas (1976-1979)

Education

  • Postdoctoral Fellowship, Department of Surgery State University of New York, Buffalo, NY, 1974-1976
  • Ph.D.,Graduate Program Physiology University of California at Davis, 1974
  • B.S.,  Department of Zoology, University of California at Davis , 1969

Websites

Teaching Interests

  • Applied Medical Physiology (Graduate)
  • Dental Physiology

Recent Grants

  1. NIH 1R01 DE026749 $1,250,000 (direct costs) 2018-2023, Title: Estradiol and Zoster Associated Orofacial Pain.  Dr. P.R. Kramer, PI, Dr. L.L. Bellinger, Co-investigator (5% effort).
  2. Estrogen and TMJ Pain.Kramer, P.R. (PI); Bellinger, L.L. (Co-PI; 17% effort).  NIH/NIDCR 1 R01 DE022129; 2012-2016, $1,000,000 (direct costs).
  3. College of Dentistry's Program for Bioengineering Science and Translational Research: "B-BEST".  D'Souza, R. (PI); Bellinger, L. (Co-Investigator); Dechow, P. (Co-Investigator).  NIH/NIDCR 1 P30 DE020742-01; 2009-2012,  $1,000,000. 
  4. Sex Steroids and TMJ Pain. Bellinger, L. (PI); Grogan, D. (Collaborator); Hutchins, B. (Collaborator); Kramer, P. (Co-PI); Spears, R. (Collaborator).   NIH/NIDCR R01 DE016059-10A1; 2005-2011, $1,500,000.
  5. Sex Steroids and TMJ Pain. Bellinger, L.; Kramer P. NIH/NIDCR 3 R01 DE01605904S1 (ARRA Supplement); summer supplement 2009, $13,185.
  6. Integrative Responses to Amino Acid Deficiencies. NIH NS 33347, 2001-2006. (PI of Subcontract, D. Gietzen, PI)

ORCID Number 0000-0002-4769-6805
Scopus Author ID 7004399616

Publications

1998 Dorsomedial hypothalamic lesions alter intake of an imbalanced amino acid diet in rats
Bellinger, L.L., J.F. Evans, and D.W. Gietzen. Dorsomedial hypothalamic lesions alter intake of an imbalanced amino acid diet in rats. J Nutr 128:1213-1217, 1998.
1999 A non-essential role of liver innervation in controlling feeding behavior
Bellinger, L.L.A non-essential role of liver innervation in controlling feeding behavior. Nutrition 15:506, 1999.
1999 Effect of dorsomedial hypothalamic nuclei knife cuts on ingestive behavior
Bellinger, L.L.and L.L. Bernardis. Effect of dorsomedial hypothalamic nuclei knife cuts on ingestive behavior. Am J Physiol 276: R1772-R1779, 1999.
1999 The effects of the dorsomedial hypothalamic nucleus on intake of an imbalanced amino acid diet
Bellinger, L.L., J.F. Evans, C.M. Tillberg, and D.W. Gietzen. The effects of the dorsomedial hypothalamic nucleus on intake of an imbalanced amino acid diet.Am J Physiol 277: R250-R262, 1999.
2002 The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation; lessons learned from lesioning studies
Bellinger L.L.and L.L. Bernardis. The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation; lessons learned from lesioning studies. Physiol Behave 76:431-442, 2002.
2003 The effects of intermittent nicotine administration on meal patterns in male rats
Bellinger, L.L.,J. Wellman and A. Cepeda-Benito. The effects of intermittent nicotine administration on meal patterns in male rats. Pharm Biochem Behave 74:495-504, 2003.
2003 Ibuprofen effects on meal patterns during acute temporomandibular joint inflammation in male and female rats
Kerins, C.A., J. E. McIntosh, D.S. Carlson and L. Bellinger. Ibuprofen effects on meal patterns during acute temporomandibular joint inflammation in male and female rats.Pharm Biochem Behave 75:181-189, 2003.
2003 Effect of i.c.v. infusion of the alpha-MSH agonist MTII on meal patterns in male rats following nicotine withdrawal
Bellinger, L.L., A. Cepeda-Benito, R.L. Bullard and P.J. Wellman. Effect of i.c.v. infusion of the alpha-MSH agonist MTII on meal patterns in male rats following nicotine withdrawal.Life Sciences 73:1861-1872, 2003.
2003 Tumor necrosis factor-alpha and apoptosis in the temporomandibular joint
Spears R., R. Oakes,L. Bellingerand B. Hutchins. Tumor necrosis factor-alpha and apoptosis in the temporomandibular joint. Archives of Oral Biology 48:825-34, 2003.
2003 A determination of tumor necrosis factor expression in TMJ inflammation using microarray analysis
Spears R., R. Oakes, C. Moore, L. Bellingerand B. Hutchins. A determination of tumor necrosis factor expression in TMJ inflammation using microarray analysis. J Dent Res 82:807-813, 2003.
2003 The prospective use of COX-2 inhibitors for the treatment of temporomandibular joint inflammatory disorders
Kerins, C.A., R. Spears, L. Bellingerand B. Hutchins. The prospective use of COX-2 inhibitors for the treatment of temporomandibular joint inflammatory disorders. International Journal of Immunopathology and Pharmacology 16:1-9, 2003.
2004 A role for cyclooxgenase II inhibitors in modulating temporomandibular joint inflammation from a meal pattern analysis perspective
Kerins, C.A., D.S. Carlson, J.E. McIntosh and L. Bellinger. A role for cyclooxgenase II inhibitors in modulating temporomandibular joint inflammation from a meal pattern analysis perspective. J Oralmaxillofacial Surgery 62:989-995, 2004.
2004 The fourth ventricle as a site of nicotine’s action on feeding behavior
Guan, P.J., L. Bellinger, and P.R. Kramer. The fourth ventricle as a site of nicotine’s action on feeding behavior.Life Sci 742725-2737, 2004.
2004 An inexpensive food cup for use in a commercially available food monitoring system
Wellman, P.J., L. Bellinger, A. Cepeda-Benito, A. Susabda, D. Ho and K. Davis. An inexpensive food cup for use in a commercially available food monitoring system.Physiol Behave 83:525-530, 2004.
2005 Effects of blocking sympathetic efferents on intake of an isoleucine imbalanced amino acid diet
Bellinger, L.L., F.E. Williams, J. Lucente, J. Palvelka and D.W. Gietzen. Effects of blocking sympathetic efferents on intake of an isoleucine imbalanced amino acid diet. Pharm Biochem Behave 81:24-31, 2005.
2005 The effects of intermittent nicotine administration on meal patterns in female rats
Bellinger, L.L., P.J. Wellman and A. Cepeda-Benito. The effects of intermittent nicotine administration on meal patterns in female rats. Pharm Biochem Behave 80:437-440, 2005.
2005 Specificity of meal pattern analysis as an animal model of determining temporomandibular joint inflammation/pain
Kerins, C.A., D.S. Carlson, R.J. Hinton, B. Hutchins, D.M. Grogan, K. Marr, P.R. Kramer, R.D. Spears and L. Bellinger. Specificity of meal pattern analysis as an animal model of determining temporomandibular joint inflammation/pain. Internet J Oral and Maxillofacial Surg 34:425-431, 2005.
2005 Adjuvant application results in altered levels of inflammatory mediators in the trigeminal ganglion and tissues of the temporomandibular joint
Spears R., L.A. Dees, M. Sapozhnikov, L. Bellingerand B. Hutchins. Adjuvant application results in altered levels of inflammatory mediators in the trigeminal ganglion and tissues of the temporomandibular joint. J Orofacial Pain19:34-40, 2005.
2005 Estrogenic effect on swelling and monocytic receptor expression in an arthritic temporomandibular joint model
Guan, G., C.A. Kerins, L. Bellingerand P.R. Kramer. Estrogenic effect on swelling and monocytic receptor expression in an arthritic temporomandibular joint model. The Journal of Steroid Biochemistry and Molecular Biology 97:241-250, 2005.
2005 Meal patterns and body weight after nicotine in male rats as a function of chow or high fat diet
Wellman, P.J., L. Bellinger, A. Cepeda-Benito, A. Susabda, D.H. Ho and K.W. Davis. Meal patterns and body weight after nicotine in male rats as a function of chow or high fat diet. Pharm Biochem Behave 82:627-34, 2005.
2007 Nicotine administration, changes in feeding behavior and the impact of NPY in rat hypothalamic nuclei
Kramer, P.R., S.F. Kramer, K. Marr, G. Guan, P.J. Wellman andL. Bellinger.Nicotine administration, changes in feeding behavior and the impact of NPY in rat hypothalamic nuclei. Regulatory Peptides 138:66-73, 2007.
2007 Meal duration as a measure of TMJ pain: the role of capsaicin-sensitive neurons in inflammation-induced TMJ nociception in female and male rats
Bellinger, L.L., R.D. Spears, C.M. King, F. Dahm, B. Hutchins, C. Kerins and P.R. Kramer. Meal duration as a measure of TMJ pain: the role of capsaicin-sensitive neurons in inflammation-induced TMJ nociception in female and male rats. Physiol Behave 90:782-789, 2007.
2007 Nicotine’s attenuation of body weight involves the perifornical hypothalamus
Kramer, P.R., G. Guan, P.J. Wellman and L. Bellinger. Nicotine’s attenuation of body weight involves the perifornical hypothalamus. Life Sci.81:500-508, 2007.
2008 Selective blockade of the rat brain aqueduct with thermogelling hydrogel nano particle dispersion
Kramer, P.R., G. Guan, Z. Zhou, Z. Hu and L. Bellinger. Selective blockade of the rat brain aqueduct with thermogelling hydrogel nano particle dispersion. Physiol. Behave. 93:546-552, 2008.
2009 The effects of cycling levels of 17beta-estradiol and progesterone on the magnitude of temporomandibular joint-induced nociception
Kramer, P.R. and L. Bellinger. The effects of cycling levels of 17beta-estradiol and progesterone on the magnitude of temporomandibular joint-induced nociception. Endocrinology150:3680-9, 2009.
2009 Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint
Puri, J., B. Hutchins,L. Bellinger, and P.R. Kramer. Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint. Reprod Biol Endocrinol 7:155, 2009.
2010 The effects of chronic nicotine on meal patterns, food intake, metabolism and body weight of male rats
Bellinger, L.L., P.J. Wellman, R.B. Harris, E.W. Kelso and P.R. Kramer. The effects of chronic nicotine on meal patterns, food intake, metabolism and body weight of male rats. Pharmacol Biochem Behave 95: 92-99, 2010.
2010 Measuring persistent temporomandibular joint nociception in rats and two mice strains
Kramer, P.R., C.A. Kerins, E. Schneiderman, andL. Bellinger. Measuring persistent temporomandibular joint nociception in rats and two mice strains. Physiol Behave 99:669-678, 2010.
2010 Knockdown of Fcy receptor III in an arthritic temporomandibular joint reduces the nociceptive response in rats
Kramer, P., J. Puri, Bellinger. Knockdown of Fcy receptor III in an arthritic temporomandibular joint reduces the nociceptive response in rats. Arthritis Rheum 62:3109-18, 2010.
2011 Estrogen in cycling rats alters gene expression in the temporomandibular joint trigeminal ganglia and trigeminal subnucleus caudalis/upper cervical cord junction
Puri J., L. Bellinger and P.R. Kramer. Estrogen in cycling rats alters gene expression in the temporomandibular joint trigeminal ganglia and trigeminal subnucleus caudalis/upper cervical cord junction. J Cellular Physiology226:3169-80, 2011.
2012 Reduced GABAA receptor alpha-6 expression on the trigeminal ganglion alters inflammatory TMJ hypersensitivity
Puri J, P. Vinothini, J. Reuben, Bellinger, L. Ailing, Y. Peng and P. Kramer. Reduced GABAA receptor alpha-6 expression on the trigeminal ganglion alters inflammatory TMJ hypersensitivity. J Neuroscience 213: 179-190, 2012.
2013 Modulation of temporomandibular joint nociception and inflammation in male rats after administering a physiological concentration of 17 beta-estradiol
Kramer, P.R., J. Puri, and L. Bellinger. Modulation of temporomandibular joint nociception and inflammation in male rats after administering a physiological concentration of 17 beta-estradiol. European Journal of Pain 17:174-184, 2013.
2013 Reduced GABAA receptor α6 expression in the trigeminal ganglion enhanced myofacial nociceptive responses
Kramer, P.R. and L. Bellinger. Reduced GABAAreceptor α6 expression in the trigeminal ganglion enhanced myofacial nociceptive responses. Neuroscience 245: 1-11, 2013.
2014 Infusion of Gabra6 siRNA into the trigeminal ganglia increased the myogenic orofacial nociception response of ovariectomized rats treated with 17beta estradiol
Kramer, P.R. and L. Bellinger. Infusion of Gabra6 siRNA into the trigeminal ganglia increased the myogenic orofacial nociception response of ovariectomized rats treated with 17beta estradiol. Neuroscience 278:144-153, 2014.
2014 Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle
Komabayashi T. , A. Wadaijkar, S. Santimano, C. Ahn, Q. Zhu, L. Opperman, L. Bellinger, J. Yang, and K.T. Nguyen. Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle. Journal of Investigative and Clinical Dentistry electronic publication on July 22, 2014; PMID: 25048311.
2015 Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral-mediated enkephalin overproduction in male and female rats
Kramer P. R. , M. Umorin, and L. Bellinger. Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral-mediated enkephalin overproduction in male and female rats. BMC Neurology 34:34(12 pages), 2015.
2015 Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral-mediated enkephalin overproduction in male and female rats
Kramer P.R., M. Umorin andL. Bellinger Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral-mediated enkephalin overproduction in male and female rats. BMC Neurology 15:34 (12 pages), 2015. DOI 10. 1186/s1286/s12883-015-0285-5. PMID: ; 5925885338 PMCID: PMC4369359.
2016 Genes in the GABA pathway increase in the lateral thalamus of Sprague Dawley rats during the proestrus/estrus phase
Umorin M, C. Stinson L. Bellinger and P.R. Kramer. Genes in the GABA pathway increase in the lateral thalamus of Sprague Dawley rats during the proestrus/estrus phase. J. Cellular Physiology 231:1057-1064, 2016. PMID: 26388520.
2017 Sex differences underlying orofacial varicella zosster associated pain in rats
Stinson C, M. Deng, M.B. Yee, L. Bellinger. P. Kinchington and P. Kramer. Sex differences underlying orofacial varicella zosster associated pain in rats. BMC Neurology 171):95 PubMed PMID:28514943; PubMed Central PMCID: PMC5436469.
2017 Distanced-based permutation of inter-meal differences as a sensitive test of temporomandibular joint nociception in rats
Umorin M., P.R. Kramer and L. Bellinger. Distanced-based permutation of inter-meal differences as a sensitive test of temporomandibular joint nociception in rats, Journal of Applied Biobehavioral Research (in press).
2019 Estrogenic effects on temporomendibular disorder and pain
Stinson, C.J. Puri, L.L. Bellinger, S.D. Bender and P.R. Kramer. Estrogenic effects on temporomendibular disorder and pain. Journal of Applied Biobehavioral Research (in press).
2017 Lateral thalamic control of nociceptive response after whisker pad injection of varicella zoster virus
Kramer P.R., Stinson C, Bellinger L.L., Umorin M., Deng M., Rao M., Yee M.B. and Kinchington P.R. Lateral thalamic control of nociceptive response after whisker pad injection of varicella zoster virus. Neuroscience (in press).
2017 Role for the ventral posterior medial/posterior lateral thalamus and anterior cingulate cortex in affective/motivation pain induced by varicella zoster virus
Kramer, P.R., J Strand, C. Stinson, L. Bellinger, P. R. Kinchington, M. B. Yee and Y. Peng. Role for the ventral posterior medial/posterior lateral thalamus and anterior cingulate cortex in affective/motivation pain induced by varicella zoster virus. Frontiers in Integrative Neuroscience October 16, 2017, doi: 10.3389/fnint.2017.00027; PMCID: PMID:29089872
2017 Distance-based permutation of inter-meal differences as a sensitive test of temporomandibular joint nociception in rats
Umorin, M., P.R. Kramer and L. Bellinger. Distance-based permutation of inter-meal differences as a sensitive test of temporomandibular joint nociception in rats,” J Appl Biobehav Res. 2017 Sep;22(3). pii: e12067. doi: 10.1111/jabr.12067. Epub 2017 Apr 18; PMCID: PMID: 29104423
2018 Effect of pregnancy on TMJ nociception in rats
Umorin M., Bellinger and P.R. Kramer. Effect of pregnancy on TMJ nociception in rats. J. Oral Science Research 34: 332-338, 2018
2018 Gi protein functions in thalamic neurons to decrease orofacial nociceptive response
Strand J, C Stinson, L. Bellinger, Y Peng and P.R. Kramer. Gi protein functions in thalamic neurons to decrease orofacial nociceptive response. Brain Research 1694:63-72, 2018.
2019 Estrogenic Effects on Temporomandibular Disorder and Pain
Stinson, C., J. Puri, L. Bellinger, S. D. Bender and P. R. Kramer. Estrogenic Effects on Temporomandibular Disorder and Pain. Journal of Applied Biobehavioral Research https://doi.org/10.1111/jabr.12164, 2019.
2019 Potential Application of Optogenetic Stimulation in the Treatment of Migraine Headache
Liu, S, Y. Tang, Y. Xing, P. Kramer, L. Bellinger and F. Tao. Potential Application of Optogenetic Stimulation in the Treatment of Migraine Headache. Brain Sciences 2019, 9, 26; doi:10.3390/brainsci9020026
2019 Estradiol acts in lateral thalamic region to attenuate varicella zoster virus associated affective pain
Stinson, C., S. M. Logan, L. Bellinger, M. Rao, P.R. Kinchington and P.R. Kramer. Estradiol acts in lateral thalamic region to attenuate varicella zoster virus associated affective pain. Neuroscience 444:99-111, 2019.
2020 A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice
Shu, H., S. Liu, Y. Tang, B. Schmidt, J. C. Dolan, L. Bellinger, P. R. Kramer, S. D. Bender and Feng Tao. A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice. Int. J. Mol. Sci. 2020, 21, 4049; doi:10.3390/ijms21114049