Phillip Kramer, PhD

Professor, Biomedical Sciences Department of Biomedical Sciences | College of Dentistry
Contact
  • 214-828-8162
  • 3302 Gaston Avenue
    Dallas, TX 75246
  • Fax: 214-874-4538
Groups and Affiliations

Biography

Career History

  • Professor, Department of Biomedical Sciences, Texas A&M University College of Dentistry (2013-present)
  • Associate Professor, Department of Biomedical Sciences, Texas A&M University College of Dentistry (2005-present)
  • Assistant Professor, Department of Biomedical Sciences, Texas A&M University College of Dentistry (2001-2005)
  • Intramural Research Training Award Fellowship, Texas A&M University, Institute of Biosciences and Technology (1997-2001)
  • Instructor, Biochemistry Laboratory Techniques, Texas A&M University, College Station, TX  (1992)

Education

  • Postdoctoral Fellowship, Neuroendocrinology National Institutes of Health, Bethesda, MD, 1997-2001
  • Postdoctoral Fellowship, Molecular Biology Texas A&M University, Institute of Biosciences and Technology, Houston, TX, 1996-1997
  • Ph.D., Biochemistry Texas A&M University, Institute of Biosciences and Technology, Houston, TX, 1996
  • B.S., Biochemistry/Cell Biology University of Minnesota, Minneapolis, 1991

Teaching Interests

  • Teaching responsibilities include:
  • Biochemistry, Cellular and Molecular Biology, Physiology

Recent Grants

  • Estrogen and TMJ Pain.  NIH/NIDCR R01 DE022129, 2012-2016; Studies the role of estrogen in modulating the pain in the TMJ.  Role: PI.
  • Sex steroids, and TMJ Pain. NIH/NIDCR R01 DE016059-10A1, 2005-2010; $1,500,000 direct costs (Bellinger, PI).  Studies the role of estrogen in modulating the pain in arthritic temporomandibular joint.  Role:  Co-investigator.
  • Intra-articular TMJ injection study of microbeads.  Appian Labs, 2008-2010; $50,000.  Role: PI.

Websites

Publications

2007 Nicotine administration effects on feeding and cocaine-amphetamine-regulated transcript (CART) expression in the hypothalamus
Kramer, P.R., Kramer, S.F., Marr, K., Guan, G., Wellman, P.J., Bellinger, L.L. (2007) Nicotine administration effects on feeding and cocaine-amphetamine-regulated transcript (CART) expression in the hypothalamus. Regul Pept. 128(2-3) 66-73.
2007 Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats
Bellinger, L.L., Spears, R.D., King, C.M., Dahm, F., Hutchins, B., Kramer, P.R. (2007). Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats. Physio Behav. 90(5) 782-789.
2007 Nicotine's attenuation of body weight involves the perifornical hypothalamus
Kramer, P.R., Guan, G., Wellman, P.J., Bellinger, L.L. (2007) Nicotine's attenuation of body weight involves the perifornical hypothalamus. Life Sciences 81(6) 500-508.
2007 17-β-estradiol utilizes the estrogen receptor to regulate CD16 expression in monocytes
Kramer, P.R., Winger, V., Kramer, S.F. (2007) 17-β-estradiol utilizes the estrogen receptor to regulate CD16 expression in monocytes. Molecular and Cellular Endocrinology 279 (102) 16-25; Epub 2007 Sept. 4.
2007 Effect of storage media on periodontal ligament cell apoptosis and expression of osteogenic characteristics
Chamorro, M., Reagan, J.D., Opperman, L., Kramer, P.R. (2007). Effect of storage media on periodontal ligament cell apoptosis and expression of osteogenic characteristics. Dental Traumatology 24(1) 11-17.
2008 Selective blockade of the rat brain aqueduct with thermogelling hydrogel nanoparticle dispersion
Kramer, P.R., Guan, G., Zhou, J., Hu, Z., Bellinger, L.L. (2008). Selective blockade of the rat brain aqueduct with thermogelling hydrogel nanoparticle dispersion. Physiology and Behavior 93:546-552.
2009 Emerging intra-articular drug delivery systems for the temporomandibular joint
Mountziaris, P.M., Kramer, P.R., Mikos, A.G. (2009). Emerging intra-articular drug delivery systems for the temporomandibular joint. Methods 47:134-140.
2009 P13K limits TNF-alpha production in CD16-activated monocytes
Kramer, P.R., Winger, V., Reuben J. (2009). P13K limits TNF-alpha production in CD16-activated monocytes. Eur J Immunol 39:561-570.
2009 Integrin-mediated attachment of periodontal ligament to titanium surfaces
Kramer, P.R., Janikkeith, A., Cai, Z., M, S., Watanabe, I. (2009). Integrin-mediated attachment of periodontal ligament to titanium surfaces. Dent Mater 25:877-883.
2009 The effects of cycling levels of 17beta-estradiol and progesterone on the magnitude of temporomandibular joint-induced nociception
Kramer, P.R., Bellinger L.L. (2009). The effects of cycling levels of 17beta-estradiol and progesterone on the magnitude of temporomandibular joint-induced nociception. Endocrinology 150:3680-9.
2009 Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint
Puri, J., Hutchins, B., Bellinger, L.L., Kramer, P.R. (2009). Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint. Reprod Biol Endocrinol 7:155.
2009 In vitro cytotoxicity evaluation of elemental ions released from different prosthodontic materials
Waleed, E., Kramer, P., Watanabe, I. (2009). In vitro cytotoxicity evaluation of elemental ions released from different prosthodontic materials. Dent Mater J 25:1551-55.
2010 The effects of chronic nicotine on meal patterns, food intake, metabolism and body weight of male rats
Bellinger, L.L., Wellman, P.J., Harris, R.B., Kelso, E.W., Kramer, P.R. (2010). The effects of chronic nicotine on meal patterns, food intake, metabolism and body weight of male rats. Pharmacol Biochem Behav. 95:92-99.
2010 Measuring persistent temporomandibular joint nociception in rats and two mice strains
Kramer, P.R., Kerins, C.A., Schneiderman, E., Bellinger, L.L. (2010). Measuring persistent temporomandibular joint nociception in rats and two mice strains. Physiol Behav 99:669-678.
2010 Intra-articular microparticles for drug delivery to the rat TMJ
Mountziaris, P.M., Sing, D.C., Mikos, A.G., Kramer, P. (2010). Intra-articular microparticles for drug delivery to the rat TMJ. J Dent Res 89:1039-44.
2010 Knockdown of Fcγ receptor III in an arthritic temporomandibular joint reduces the nociceptive response in rats
Kramer, P., Puri, J., Bellinger, L. (2010). Knockdown of Fcγ receptor III in an arthritic temporomandibular joint reduces the nociceptive response in rats. Arthritis Rheum 62:3109-18.
2011 Estrogen in cycling rats alters gene expression in the temporomandibular joint, trigeminal ganglia and trigeminal subnucleus/upper cervical cord junction
Puri, J., Bellinger, L.L., Kramer, P.R. (2011). Estrogen in cycling rats alters gene expression in the temporomandibular joint, trigeminal ganglia and trigeminal subnucleus/upper cervical cord junction. J Cell Physiol 226:3169-80.
2011 Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility
Messina, A., Ferraris, N., Wray, S., Cagnoni, F., Donohue, D., Casoni, F., Kramer, P., Derijck, A., Adolfs, Y., Fasolo, A., Pasterkamp., R., Giacobini, P. (2011). Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility. Hum Mol Genet 20:4759-74.
2012 Reduced GABA(A) receptor α6 expression in the trigeminal ganglion alters inflammatory TMJ hypersensitivity
Puri, J., Vinothini, P., Reuben, J., Bellinger, L.L., Ailing, L., Peng, Y.B., Kramer, P.R. (2012). Reduced GABA(A) receptor α6 expression in the trigeminal ganglion alters inflammatory TMJ hypersensitivity. Neuroscience 214:179-190.
2012 Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymermicroparticles ameliorates temporomandibular joint inflammation
Mountziaris, P.M., Tzounas, S.N., Sing, D.S.C., Kramer, P.R., Kasper, F.K., Mikos, A.G. (2012). Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymermicroparticles ameliorates temporomandibular joint inflammation. Acta Biomater 8:3552-60.
2012 A non-invasive model for measuring nociception after tooth pulp exposure
Kramer, P.R., He, J., Puri, J., Bellinger, L.L. (2012). A non-invasive model for measuring nociception after tooth pulp exposure. J Dent Res 91:883-887.
2013 Modulation of temporomandibular joint nociception and inflammation in male rats after administering a physiological concentration of 17β-oestradiol
Kramer, P.R., Bellinger L.L. (2013). Modulation of temporomandibular joint nociception and inflammation in male rats after administering a physiological concentration of 17β-oestradiol. Eur J Pain 17:174-184.
2013 Reduced GABAA receptor α6 expression in the trigeminal ganglion enhanced myofacial nociceptive responses
Kramer, P.R., Bellinger L.L. (2013). Reduced GABAA receptor α6 expression in the trigeminal ganglion enhanced myofacial nociceptive responses. Neuroscience 245:1-11.
2014 Infusion of Gabra6 siRNA into the trigeminal ganglia increased the myogenic orofacial nociception response of ovarectomized rats treated with 17beta estradiol
Kramer, P.R., Bellinger L.L. (2014). Infusion of Gabra6 siRNA into the trigeminal ganglia increased the myogenic orofacial nociception response of ovarectomized rats treated with 17beta estradiol. Neuroscience 278:144-153.
2015 Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral mediated enkephalin overproduction in male and female rats
Kramer P.R., Umorin M., Bellinger L.L. (2015). Attenuation of myogenic orofacial nociception and mechanical hypersensitivity by viral mediated enkephalin overproduction in male and female rats. BMS Neurology 15: 34.