Texas A&M University College of Dentistry

Yan Jing, DMD, PhD

Assistant Professor Department of Orthodontics | College of Dentistry
Contact
  • 214-370-7203
  • 3302 Gaston Avenue
    Dallas, TX 75246
  • Fax: 214-874-4569
Groups and Affiliations

Biography

Dr. Yan Jing is clinician scientist who is trained in both basic and clinical sciences directly linked to mandibular biology and orthodontics. Her main researches focus on the key roles of chondrocyte-derived bone cells in condylar development and remodeling. As a joined trained Ph.D. student and then postdoctoral fellow, she spent over three years in Dr. Jian Q. Feng’s lab (Dallas, TX) on learning in vivo gene knockout studies, cell lineage tracing, Laser capture, and different histological imaging techniques. Since then, Dr. Jing was promoted to Research Assistant Professor in the Department of Orthodontics in Texas A&M University College of Dentistry.

Dr. Jing's major contribution to the field is to demonstrate that direct transformation of chondrocytes into bone cells is a critical developmental event during condyle development, rather than the old concept of hypertrophic chondrocyte apoptosis followed by bone marrow cell invasion. Our recent publication entitled “Chondrocytes Directly Transform into Bone Cells in Mandible Condyle Growth” was selected as the cover of the year in JDR 2015 and William J. Gies Award for Biological Research in JDR 2017 (JDR, Journal of Dental Research, the best one in dentistry). In addition, Dr. Jing has published 16 manuscripts and has won several Young Investigator Awards (shown in the “Honors”) in the last six years.

Education

  • Postdoc (Skeletal biology) Texas A&M University College of Dentistry, 2016
  • Ph.D., Stomatology (Orthodontics) Sichuan University, 2014
  • Joint Training, Ph.D. Student, Biomedical Sciences Texas A&M University College of Dentistry, 2014
  • M.S., Stomatology (Orthodontics) Sichuan University, 2011
  • DMD Xi’an Jiaotong University, Xi’an, Shaanxi, China, 2008
  • B.S., Stomatology Xi’an Jiaotong University, 2008

Awards & Honors

  • AIMM/ASBMR John Haddad Young Investigator Award, April 2018;
  • William J. Gies Award for Biological Research in the Journal of Dental Research (Best journal in Dentistry), 2017 (First author in the paper: Chondrocytes Directly Transform into Bone Cells in Mandibular Condyle Growth, J Dent Res 94(12):1668-1675);
  • The Cover of the year 2015 in the Journal of Dental Research (Best journal in Dentistry), 2015 (First author in the paper: Chondrocytes Directly Transform into Bone Cells in Mandibular Condyle Growth, J Dent Res 94(12):1668-1675);
  • Best Poster in 2014 annual meeting for the Orthopaedic Research Society, March 2015;
  • ASBMR Young Investigator Award in 2014 annual meeting for American Society for Bone and Mineral Research, September 2014;
  • Osteoarthritis Young Investigator Award in 44th International Sun Valley workshop, August 2014;
  • ORS Web Jee Young Investigator Award in 2014 annual meeting for Orthopaedic Research Society, March 2014;Selected Publications

Recent Grants

  • The novel roles of tendon in TMJ condyle formation and remodeling. NIH/NIDCR R03DE029541, 04/20-03/22, PI
  • To define the novel roles of endochondrogenesis in mandible formation and trauma repair. NIH/NIDCR K08DE028593, 12/20-11/25, PI
  • Development of sustained fluoride-releasing O-rings for the prevention of white spot lesions. AAOF/BRA, 07/20-06/21, PI
  • Novel roles of chondrocyte-derived bone cells in mechanical strain-induced TMJ remodeling. AAOF/BRA, 07/17-06/18, PI

Publications

2021 ScxLin cells directly form a subset of chondrocytes in temporomandibular joint that are sharply increased in Dmp1-null mice
Ma C, Jing Y, Li H, Wang K, Wang Z, Xu C, Sun X, Kaji D, Han X, Huang A, Feng J (2021). ScxLin cells directly form a subset of chondrocytes in temporomandibular joint that are sharply increased in Dmp1-null mice. Bone (Co-first author, corresponding author)
2020 Chondrogenesis Defines Future Skeleton Patterns via Cell Transdifferentiation from Chondrocytes to Bone Cells
Jing Y, Wang Z, Li H, Ma C, Feng J. (2020) Chondrogenesis Defines Future Skeleton Patterns via Cell Transdifferentiation from Chondrocytes to Bone Cells. Current Osteoporosis Reports (Co-corresponding author)
2019 Hypophosphatemic rickets accelerate chondrogenesis and cell trans-differentiation from TMJ chondrocytes into bone cells via a sharp increase in β-catenin
Li H, Jing Y, Zhang R, Zhang Q, Wang J, Martin A, Feng J. (2019) Hypophosphatemic rickets accelerate chondrogenesis and cell trans-differentiation from TMJ chondrocytes into bone cells via a sharp increase in β-catenin. Bone
2019 SOST Deficiency Aggravates Osteoarthritis in Mice by Promoting Sclerosis of Subchondral Bone
Li J, Xue J, Jing Y, Wang M, Shu R, Xu H, Xue C, Feng J, Wang P, Bai D. (2019) SOST Deficiency Aggravates Osteoarthritis in Mice by Promoting Sclerosis of Subchondral Bone. BioMed Res Int
2018 Bio‐Inspired micropatterned platforms recapitulate 3D physiological morphologies of bone and dentinal cells
Ma C, Chang B, Jing Y, Kim H, Liu X. (2018) Bio‐Inspired micropatterned platforms recapitulate 3D physiological morphologies of bone and dentinal cells. Adv Sci DOI: 10.1002/advs.201801037
2018 Dentinal mineralization is not limited in the mineralization front but occurs along with the entire odontoblast process
Li C*, Jing Y*, Wang K, Ren Y, Liu X, Wang X, Wang Z, Zhao H, Feng J. (2018). Dentinal mineralization is not limited in the mineralization front but occurs along with the entire odontoblast process. Int J Biol Sci 14(7):693-704 (*equally contribute to this work)
2018 Vital roles of b-catenin in trans-differentiation of chondrocytes to bone cells
Jing Y, Jing J, Wang K, Chan K, Harris S, Hinton R, Feng J (2018). Vital roles of b-catenin in trans-differentiation of chondrocytes to bone cells Int J Biol Sci 14(1):1-9 (Co-corresponding author)
2018 3D Maskless Micropatterning for Regeneration of Highly Organized Tubular Tissues
Ma C, Qu T, Chang B, Jing Y, Feng JQ, Liu X (2018). 3D Maskless Micropatterning for Regeneration of Highly Organized Tubular Tissues. Adv Healthc Mater 7(3) doi: 10.1002/adhm.201700738
2017 Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process
Jing Y, Jing J, Ye L, Liu X, Harris S, Hinton R, Feng J (2017). Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological process. Sci Rep 7(1):10020. doi: 10.1038/s41598-017-10048-z (Co-corresponding author)
2017 Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair
Hinton R, Jing Y, Jing J, Feng JQ (2017). Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair. J Dent Res 96(1):23-30
2016 Co-localization of Cell Lineage Markers and Tomato Signal
Jing Y, Hinton R, Chan K, Feng JQ (2016). Co-localization of Cell Lineage Markers and Tomato Signal. J Vis Exp 28(118) doi: 10.3791/54982 (Co-corresponding author)
2016 miRNA-101 acts as a tumor suppressor in oral squamous cell carcinoma by targeting CX chemokine receptor 7
Hui Y, Li Y, Jing Y, Feng JQ, Ding Y (2016). miRNA-101 acts as a tumor suppressor in oral squamous cell carcinoma by targeting CX chemokine receptor 7. Am J Transl Res 15;8(11):4902-4911
2016 Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23
Ren Y, Han X, Jing Y, Yuan B, Ke H, Liu M, Feng JQ (2016). Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23. Matrix Biol 52-54:151-161.