Yongbo Lu, PhD, MD, MS

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2018 Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice

Zhang H, Xie X, Liu P, Liang T, Lu Y, Qin C. Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice. PLoS One. 2018 Apr 19;13(4):e0195854. PMID: 29672573

2018 Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs

Lu Y, Kamel-El Sayed SA, Wang K, Tiede-Lewis LM, Grillo MA, Veno PA, Dusevich V, Phillips CL, Bonewald LF, Dallas SL. Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs. J Bone Miner Res. 2018 Jun;33(6):1166-1182. PMID: 29461659

2018 FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner

Liu C, Zhang H, Jani P, Wang X, Lu Y, Li N, Xiao J, Qin C. FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner. J Cell Physiol. 2018 Apr;233(4):3476-3486. PMID: 28926103

2017 Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia

Liu P, Ma S, Zhang H, Liu C, Lu Y, Chen L, Qin C. Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia. Sci Rep. 2017 Jun 15;7(1):3590. PMID: 28620244

2017 Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice

Zhang H, Jani P, Liang T, Lu Y, Qin C. Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of molecular histology. 2017 Apr;48(2):83-98. PMID: 28000152

2016 Transgenic expression of dentin phosphoprotein inhibits skeletal development

Zhang H, Liu P, Wang S, Liu C, Jani P, Lu Y, Qin C. Transgenic expression of dentin phosphoprotein inhibits skeletal development. European journal of histochemistry. 2016 Mar 11;60(1):2587. PMCID: PMC4800252

2016 Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice

Jani PH, Gibson MP, Liu C, Zhang H, Wang X, Lu Y, Qin C. Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix biology. 2016; 52-54:95-112. PMCID: PMC4875789

2016 Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression

Xie X, Liu C, Zhang H, Jani PH, Lu Y, Wang X, Zhang B, Qin C. Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression. Scientific reports. 2016 May 5;6:25364. PMCID: PMC4857113

2016 The LPV motif is essential for the efficient export of secretory DMP1 from the endoplasmic reticulum

Liang T, Meng T, Wang S, Qin C, and Lu Y. The LPV motif is essential for the efficient export of secretory DMP1 from the endoplasmic reticulum. Journal of cellular physiology. 2016 Jul;231(7):1468-75. PMCID: PMC4801704

2015 Twist1 is Essential for Tooth Morphogenesis and Odontoblast Differentiation

Meng T, Huang Y, Wang S, Zhang H, Dechow PC, Wang X, Qin C, Shi B, D'Souza RN, Lu Y. Twist1 is Essential for Tooth Morphogenesis and Odontoblast Differentiation. The Journal of biological chemistry. 2015 Dec 4;290(49):29593-602. PMCID: PMC4705958

2015 Immortalized mouse floxed Fam20c dental papillar mesenchymal and osteoblast cell lines retain their primary characteristics

Liu C, Wang X, Zhang H, Xie X, Liu P, Liu Y, Jani PH, Lu Y, Chen S, Qin C. Immortalized mouse floxed Fam20c dental papillar mesenchymal and osteoblast cell lines retain their primary characteristics. Journal of cellular physiology. 2015 Nov;230(11):2581-7. PMCID: PMC5004989

2015 Novel approaches for two and three dimensional multiplexed imaging of osteocytes

Kamel-ElSayed SA, Tiede-Lewis LM, Lu Y, Veno PA, Dallas SL. Novel approaches for two and three dimensional multiplexed imaging of osteocytes. Bone. 2015 Jul;76:129-40. PMCID: PMC4591054

2014 Twist1- and Twist2-haploinsufficiency results in reduced bone formation

Huang Y, Meng T, Wang S, Zhang H, Mues G, Qin C, Feng JQ, D’Souza RN, Lu Y. Twist1- and Twist2-haploinsufficiency results in reduced bone formation. PLoS One. 2014 Jun 27;9(6):e99331. PMCID: PMC4074031

2014 Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice

Lin SX, Zhang Q, Zhang H, Yan K, Ward L, Lu YB, Feng JQ. Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice. International journal of oral science. 2014 Sep;6(3):133-41. PMCID: PMC4170153

2014 Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype

Lin S, Zhang Q, Cao Z, Lu Y, Zhang H, Yan K, Liu Y, Mckee MD, Qin C, Chen Z, Feng JQ. Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. The Journal of biological chemistry. 2014 Aug 1;289(31):21533-43. PMCID: PMC4118114

2014 Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice

Gibson MP, Jani P, Wang X, Lu Y, Qin C. Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice. Journal of oral biosciences. 2014 Nov 1;56(4):143-148. PMCID: PMC4224573

2013 The specific role of FAM20C in amelogenesis

Wang X, Jung J, Liu Y, Yuan B, Lu Y, Feng JQ, Qin C. The specific role of FAM20C in amelogenesis. Journal of Dental Research. Journal of dental research. 2013 Nov; 92(11):995-9. PMCID: PMC3797537

2013 Twist1 Controls Lung Vascular Permeability and Endotoxin-induced Pulmonary Edema by Altering Tie2 Expression

Mammoto T, Jiang E, Jiang A, Lu Y, Juan AM, Chen J, Mammoto A. Twist1 Controls Lung Vascular Permeability and Endotoxin-induced Pulmonary Edema by Altering Tie2 Expression. PLoS One. 2013 Sep 2;8(9):e73407. PMCID: PMC3759405

2013 Functional evaluation of a novel tooth agenesis-associated bone morphogenetic protein 4 prodomain mutation

Huang Y, Lu Y, Mues G, Wang S, Bonds J, D'Souza R. Functional evaluation of a novel tooth agenesis-associated bone morphogenetic protein 4 prodomain mutation. European journal of oral sciences. 2013 Aug;121(4):313-8. PMCID: PMC3711029

2013 Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis

Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng JQ, Qin C. Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. European journal of oral sciences. 2013 Apr;121(2):76-85. PMCID: PMC3602929

2013 The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis

Gibson MP, Zhu Q, Wang S, Liu Q, Liu Y, Wang X, Yuan B, Ruest LB, Feng JQ, D'Souza RN, Qin C, Lu Y. The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. Journal of biological chemistry. 2013 Mar 8;288(10):7204-14. PMCID: PMC3591629

2012 Proteolytic processing of Dentin Sialophosphoprotein (DSPP) is essential to dentinogenesis

Zhu Q, Gibson MP, Liu Q, Liu Y, Lu Y, Wang X, Feng JQ, Qin C. Proteolytic processing of Dentin Sialophosphoprotein (DSPP) is essential to dentinogenesis. The Journal of biological chemistry. 2012 Aug 31;287(36):30426-35. PMCID: PMC3436292

2012 FAM20C plays an essential role in the formation of murine teeth

Wang X, Wang S, Lu Y, Gibson MP, Liu Y, Yuan B, Feng JQ, Qin C. FAM20C plays an essential role in the formation of murine teeth. The Journal of biological chemistry. 2012 Oct 19;287(43):35934-42. PMCID: PMC3476261

2012 Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice

Wang X, Wang S, Li C, Gao T, Liu Y, Rangiani A, Sun Y, Hao J, George A, Lu Y, Groppe J, Yuan B, Feng JQ, Qin C. Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS genetics. 2012;8(5):e1002708. PMCID: PMC3355082

2012 Nuclear localization of DMP1 proteins suggests a role in intracellular signaling

Siyam A, Wang S, Qin C, Mues G, Stevens R, D'Souza RN, Lu Y. Nuclear localization of DMP1 proteins suggests a role in intracellular signaling. Biochemical and biophysical research communications. 2012 Aug 3;424(3):641-6. PMCID: PMC3412887

2012 Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling

Lu Y, Li Y, Cavender AC, Wang S, Mansukhani A, D'Souza RN. Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling. Developmental dynamics. 2012 Nov;241(11):1708-15. PMCID: PMC4153435

2012 Partial blocking of mouse DSPP processing by substitution of Gly(451)-Asp(452) bond suggests the presence of secondary cleavage site(s)

Zhu Q, Prasad M, Kong H, Lu Y, Sun Y, Wang X, Yamoah A, Feng JQ, Qin C. Partial blocking of mouse DSPP processing by substitution of Gly(451)-Asp(452) bond suggests the presence of secondary cleavage site(s). Connective tissue research. 2012;53(4):307-12. PMCID: PMC3676176

2012 Protective Roles of DMP1 in High Phosphate Homeostasis

Rangiani A, Cao Z, Sun Y, Lu Y, Gao T, Yuan B, Rodgers A, Qin C, Kuro OM, Feng JQ. Protective Roles of DMP1 in High Phosphate Homeostasis. PLoS One. 2012;7(8):e42329. PMCID: PMC3411740

2011 Unique roles of phosphorus in endochondral bone formation and osteocyte maturation

Zhang R, Lu Y, Ye L, Yuan B, Yu S, Qin C, Xie Y, Gao T, Drezner MK, Bonewal LF, Feng JQ. Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2011;26(5):1047-56. PMCID: PMC3179305

2011 DMP1 processing is essential to dentin and jaw formation

Sun Y, Lu Y, Chen L, Gao T, D'Souza R, Feng JQ, Qin C. DMP1 processing is essential to dentin and jaw formation. Journal of dental research. 2011;90(5):619-24. PMCID: PMC3077457

2011 The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment

Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF, Feng JQ. The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2011;26(2):331-40. PMCID: PMC3179348

2011 TWIST1 promotes the odontoblast-like differentiation of dental stem cells

Li Y, Lu Y, Maciejewska I, Galler KM, Cavender A, D'Souza RN. TWIST1 promotes the odontoblast-like differentiation of dental stem cells. Advances in dental research. 2011;23(3):280-4. PMCID: PMC3144037

2011 FGF23 in skeletal modeling and remodeling

Lu Y, Feng JQ. FGF23 in skeletal modeling and remodeling. Current osteoporosis reports. 2011;9(2):103-8. PMCID: PMC3268056

2010 Key proteolytic cleavage site and full-length form of DSPP

Sun Y, Lu Y, Chen S, Prasad M, Wang X, Zhu Q, Zhang J, Ball H, Feng J, Butler WT, Qin C. Key proteolytic cleavage site and full-length form of DSPP. Journal of dental research. 2010;89(5):498-503. PMCID: PMC2873034

2010 Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus

Lv K, Huang H, Lu Y, Qin C, Li Z, Feng JQ. Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus. International journal of biological sciences. 2010;6(6):537-45. PMCID: PMC2945924

2010 DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype

Jiang B, Cao Z, Lu Y, Janik C, Lauziere S, Xie Y, Poliard A, Qin C, Ward LM, Feng JQ. DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2010;25(10):2155-64. PMCID: PMC3153318

2009 Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues

Peng T, Huang B, Sun Y, Lu Y, Bonewald L, Chen S, Butler WT, Feng JQ, D’Souza RN, Qin C. Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells Tissues Organs. 2009;189(1-4):192-7. PMCID: PMC2666981

2009 Studies of the DMP1 57-kDa functional domain both in vivo and in vitro

Lu Y, Qin C, Xie Y, Bonewald LF, Feng JQ. Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells Tissues Organs. 2009;189(1-4):175-85. PMCID: PMC2667139

2008 Identification of full-length dentin matrix protein 1 in dentin and bone

Huang B, Maciejewska I, Sun Y, Peng T, Qin D, Lu Y, Bonewald L, Butler WT, Feng JQ, Qin C. Identification of full-length dentin matrix protein 1 in dentin and bone. Calcified tissue international. 2008;82(5):401-10. PMCID: PMC2666980

2007 Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo

Lu Y, Ye L, Yu S, Zhang S, Xie Y, McKee MD, Li YC, Kong J, Eick JD, Dallas SL, Feng JQ. Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Developmental biology. 2007;303(1):191-201. PMCID: PMC2059935

2007 Use of the transgenic approach to determine the role of DMP1 in phosphate regulation

Lu Y, Liu S, Xie Y, Yu S, Quarles L, Bonewald LF, Feng JQ. Use of the transgenic approach to determine the role of DMP1 in phosphate regulation. Journal of musculoskeletal & neuronal interactions. 2007;7(4):309. PMID: 18094487

2007 DMP1-targeted Cre expression in odontoblasts and osteocytes

Lu Y, Xie Y, Zhang S, Dusevich V, Bonewald LF, Feng JQ. DMP1-targeted Cre expression in odontoblasts and osteocytes. Journal of dental research. 2007;86(4):320-5. PMID: 17384025

2006 E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation

Zhang K, Barragan-Adjemian C, Ye L, Kotha S, Dallas M, Lu Y, Zhao S, Harris M, Harris SE, Feng JQ, Bonewald LF. E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation. Molecular and cellular biology. 2006;26(12):4539-52. PMCID: PMC1489126

2006 Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nature genetics. 2006;38(11):1310-5. PMCID: PMC1839871

2005 Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo

Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha SE, Bonewald LF, Feng JQ, Rowe DW, Turner CH, Robling AG, Harris S. Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. The Journal of biological chemistry. 2005;280(21):20680-90. PMID: 15728181

2005 Differential regulation of dentin matrix protein 1 expression during odontogenesis

Lu Y, Zhang S, Xie Y, Pi Y, Feng JQ. Differential regulation of dentin matrix protein 1 expression during odontogenesis. Cells Tissues Organs. 2005;181(3-4):241-7. PMID: 16612089

2005 DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis

Ling Y, Rios HF, Myers ER, Lu Y, Feng JQ, Boskey AL. DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. Journal of bone and mineral research. 2005;20(12):2169-77. PMCID: PMC1456072

2004 Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development

Ye L, MacDougall M, Zhang S, Xie Y, Zhang J, Li Z, Lu Y, Mishina Y, Feng JQ. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. The Journal of biological chemistry. 2004;279(18):19141-8. PMID: 14966118

2003 The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development

Feng JQ, Huang H, Lu Y (co-first author), Ye L, Xie Y, Tsutsui TW, Kunieda T, Castranio T, Scott G, Bonewald LB, Mishina Y. The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. Journal of dental research. 2003;82(10):776-80. PMID: 14514755

2002 Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles

Zhang J, Tan X, Contag CH, Lu Y, Guo D, Harris SE, Feng JQ. Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles. Biochemical and biophysical research communications. 2002;293(5):1412-9. PMID: 12054672

2002 Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo

Feng JQ, Zhang J, Tan X, Lu Y, Guo D, Harris SE. Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo. Journal of dental research. 2002;81(1):6-10. PMID: 11820370

2002 Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene

Fen JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE, MacDougall M. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002;17(10):1822-31. PMID: 12369786