Gokul Gopinathan

Biography

Dr. Gopinathan is currently a Research Assistant Professor in the Center for Craniofacial Research and Diagnosis.

Gokul is currently interested in two areas of research (i) the function of the CFDP1 gene in mouse craniofacial development and (ii) the genetic and epigenetic factors contributing toward mineralized state homeostasis of the periodontal region.

From 2005 until 2009, Gokul worked on topics related to cancer epigenetics at the Center for DNA Fingerprinting and Diagnostics in Hyderabad, India. Subsequently, he worked on deciphering the epigenetic mechanisms regulating dental mesenchymal stem cell fate as a post-doctoral researcher at the University of Illinois, Chicago until 2015.

Contributions to Journals:

Zhou, X., Luan, X., Chen, Z., Francis, M., Gopinathan, G., Li, W., Lu, X., Li, S., Wu, C., Diekwisch, T.G.H. (2016). MicroRNA-138 inhibits periodontal progenitor differentiation under inflammatory conditions. Journal of Dental Research. 95(2):230-7.

Gopinathan, G., Jin, T., Liu, M., Li, S., Atsawasuwan, P., Galang, M.T., Allen, M., Luan, X., Diekwisch, T.G. (2014). The expanded amelogenin polyproline region preferentially binds to apatite versus carbonate and promotes apatite crystal elongation. Front Physiol. 5:430

Li, Q., Reed, D.A., Min, L., Gopinathan, G., Li, S., Dangaria, S.J., Li, L., Geng, Y., Galang, M.T., Gajendrareddy, P., Zhou, Y., Luan, X., Diekwisch, T.G. (2014). Lyophilized Platelet-Rich Fibrin (PRF) Promotes craniofacial bone regeneration through Runx2. Int J Mol Sci 15(5): 8509-25.

Gopinathan, G., Kolokythas, A., Luan, X., Diekwisch, T.G. (2013). Epigenetic marks define the lineage and differentiation potential of two distinct neural crest-derived intermediate odontogenic progenitor populations. Stem Cells Dev 22(12): 1763-78.

Pan, S., Dangaria, S.J., Yan, X., Gopinathan, G., Lu, X., Kolokythas,A., Niu, X., Luan, X.  (2013). SCF promotes dental pulpprogenitor migration, neovascularization, and collagen remodeling-potential applications as a homing factor in pulp regeneration.  StemCell Rev. 9(5): 655-67.

Atsawasuwan, P., Lu, X., Ito, Y., Chen, Y., Gopinathan, G., Evans, C.A.,Kulkarni, A.B., Gibson, C.W., Luan, X., Diekwisch, T.G.H. (2013).  Expression and function of Enamel-related gene products in calvarial development. J Dent Res 92(7): 622-8.

Li, Q., Pan, S., Dangaria, S.J., Gopinathan, G., Kolokythas, A., Chu, S.,Geng, Y., Zhou, Y., Luan, X. (2013). Platelet-rich fibrin (PRF)promotes periodontal regeneration and enhances alveolar boneaugmentation. Biomed Res Int. 2013: 638043.

Gokul, G.,and Khosla, S. (2012). DNA methylation and cancer. Subcell Biochem (Springer) 61:597-625.

Manderwad, G.P., Gokul, G., Khosla, S., Chitra, Kannabiran., Santosh, G, Honavar., Geeta, K, Vemuganti. (2010). Hypomethylation of DNMT3Lpromoter region in ocular surface squamous Neoplasia (OSSN). Arch Pathol Lab Med 134:1193-6.

Gokul, G., Ramakrishna, G., Khosla, S. (2009). Reprogramming of HeLa cells upon DNMT3Loverexpression mimics carcinogenesis. Epigenetics4: 322-9.

Gokul, G., Gautami, B., Malathi, S., Sowjanya, A.P., Poli, U.R., Jain, M., Ramakrishna, G., Khosla, S. (2007). DNA Methylation Profile at the DNMT3LPromoter: A potential biomarker for Cervical cancer. Epigenetics 2: 80-85.

Srinivas, P., Gopinath, G., Banerji, A., Dinakar, A., Srinivas, G. (2004). Plumbagin induces Reactive Oxygen species which mediates apoptosis in human cervical cancer cells. Molecular Carcinogenesis 40: 201-11.

Srinivas, G., Annab, L.A., Gopinath, G., Banerji, A., Srinivas, P. (2004). Antisense blocking of BRCA1enhances sensitivity to Plumbagin but not tamoxifen in BG1 ovarian cancer cells. Molecular Carcinogenesis39: 15-25.