Clinical Trials and Studies
Now Recruiting
Do you Snore, Mouth Breathe and have Periodontitis?
You may be eligible to participate in a research study using oral appliance therapy to treat snoring and improve your sleep, breathing, and periodontal health
Snoring, mouth breathing, and periodontitis can be serious problems that affect your overall health. They are associated with poor quality sleep, high blood pressure, heart disease and dementia.
Texas A&M University School of Dentistry researchers are conducting a study on an oral appliance that may improve periodontitis in addition to sleep quality.
Periodontitis is inflammation of gums and tissues that support the teeth; if untreated, can lead to bone loss and the loosening of teeth as well as tooth loss.
Eligibility: You may qualify if you have mild to moderate periodontitis (we will confirm), and are at least 18 years old, and snore and mouth breathe, and have adequate dental health to wear an oral appliance.
Requirements: The study involves about 7 visits over a 12- to 14-week period to the Texas A&M University School of Dentistry, 3302 Gaston Avenue, Dallas, TX. It involves doing home sleep tests for at least 9 nights and wearing an oral appliance with a mouth shield at night for 12 weeks.
Benefits, Risks & Compensation: Potential benefits include reduction of snoring; improved breathing, sleep quality and periodontal health. Potential risks & discomforts are minimal. You will receive diagnostic x-rays and deep cleaning of all your teeth (standard treatment for periodontitis) and get to keep the custom-fitted oral appliance at the completion of the study. There is no cost to you to participate or for the dental care that we will provide as part of the study.
Study Title: myTAPOral Appliance Plus Mouth Shield to Reduce Periodontitis in Mouth-Breathers who Snore.
Principal Investigators: Dr. Emet Schneiderman, eschneiderman@tamu.edu, Dr. Preetam Schramm, schramm@tamu.edu
For more information, contact: Ms. Zohre German (Clinic Coordinator) at 214-828-8291 or german@tamu.edu
IRB NUMBER: IRB2022-1450-CD-FB IRB APPROVAL DATE: 03/02/2023
Ongoing Studies
Pregnancy and Sleep Quality Study
You may be able to improve your sleep and quality of Life
For more information, contact: Ms. Zohre German (Study Coordinator) 214-828-8291 or german@tamu.edu
Consider participating in a research study using oral appliance therapy to treat snoring, improve sleep and breathing.
Texas A&M University College of Dentistry researchers are conducting a pilot study on the effectiveness of an oral appliance to improve sleep quality, breathing & snoring.
Snoring can be a serious problem that can affect your health and that of your developing child. It is associated with poor quality sleep, high blood pressure, heart disease, preeclampsia and preterm delivery.
Eligibility: If you are pregnant, at least 18 years old, and snore, and have adequate dental health to wear an oral appliance, you may qualify.
Requirements: The study is 5-weeks long and requires regular visits to the Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas, TX. The study involves doing home sleep tests for at least 6 nights, & wearing an oral appliance at night for 4 weeks.
Benefits, Risks & Compensation: Potential benefits include reduction of snoring; improved breathing and sleep quality.
Potential risks & discomforts are minimal. Compensation of $150 will be provided and you will be able to keep the custom-fitted oral appliance at the completion of the study. There is no cost to you to participate.
Study Title: Oral Appliance Therapy for Improving Sleep Quality during Pregnancy: A Controlled Clinical Trial
Principal Investigators: Dr. Emet Schneiderman, eschneiderman@tamu.edu, Dr. Preetam Schramm, schramm@tamu.edu
Funded by: The Baylor Oral Health Foundation and Airway Management Inc.
For more information, contact: Ms. Zohre German (Study Coordinator) 214-828-8291 or german@tamu.edu
IRB NUMBER: 2018-0048-CD-EXP IRB APPROVAL DATE: 05/24/2018
Atrial Fibrillation and Sleep Study
Improve your Sleep and Quality of Life
You may be eligible to participate in a research study using oral appliance therapy to treat snoring, improve sleep and breathing.
Texas A&M University College of Dentistry researchers are conducting a pilot study on the effectiveness of an oral appliance to improve sleep quality, breathing & snoring.
Snoring can be a serious problem that can affect your health. Atrial fibrillation increases the risk of death in patients with sleep-disordered breathing compared with patients without any sleep-disordered breathing.
Eligibility: If you are a patient with diagnosed atrial fibrillation, have an implanted fibrillation monitor and at least 8 teeth per dental arch to support a dental oral appliance, you may qualify.
For more information, contact: Ms. Zohre German (Study Coordinator) 214-828-8291 or german@tamhsc.edu
Study Title: Oropharynx-Brainstem-Heart Connection: A controlled clinical trial to assess atrial fibrillation attenuation in patients treated with oral appliance therapy
IRB NUMBER: 2018-0954-CD-EXP, IRB APPROVAL DATE: 11/01/2018
Completed Studies
Schramm P, Das N, Schneiderman E, German Z, Hui J, Wilson D, Spence JS, Moura P, Chapman SB. Snoring Remediation with Oral Appliance Therapy Potentially Reverses Cognitive Impairment: An Intervention Controlled Pilot Study. Geriatrics. 2021; 6(4):107. https://doi.org/10.3390/geriatrics6040107
Schneiderman E, Schramm P, Hui J, Wilson PD, Moura P, German Z, McCann A, Newton M. Randomized Trial of 2 Self-Titrated Oral Appliances for Airway Management. Journal of Dental Research. 2020 Sep:22034520956977. DOI: 10.1177/0022034520956977.
https://journals.sagepub.com/doi/10.1177/0022034520956977
Newton M, Schneiderman E, Hui J, Wilson D, Moura P, German Z, Schramm P. Prescribed Medications Confound Oral Appliance Therapy in Obstructive Sleep Apnea. Journal of Dental Research, Special Issue, Abstract #3599, 2020. https://iadr.abstractarchives.com/abstract/20iags-3322317/prescribed-medications-confound-oral-appliance-therapy-in-obstructive-sleep-apnea
Newton M, Schneiderman E, Hui J, Wilson PD, Moura P, German Z, McCann A, Bender B, Schramm P. Oral Appliances Efficacious in Treating Severe Obstructive Sleep Apnea Patients. Journal of Dental Research 97, Special Issue A, Abstract # 2089, 2019. https://iadr.abstractarchives.com/abstract/19iags-3186937/oral-appliances-efficacious-in-treating-severe-obstructive-sleep-apnea-patients
There are no other clinical trials or studies requiring participants at this time.