Madhu Shrestha

Madhu Shrestha, PhD, MS, MDS, BDS

Clinical Assistant Professor

Contact

Department of Diagnostic Sciences
3302 Gaston Ave.
Dallas, TX 75246
madhushrestha@tamu.edu
Phone: 214.828.8116

Biography

Dr. Madhu Shrestha is a Clinical Assistant Professor in the department of Diagnostic Sciences, at Texas A&M University School of Dentistry. She is a fellow of the American Academy of Oral & Maxillofacial Pathology and a diplomate of the American Board of Oral & Maxillofacial Pathology. Dr. Shrestha received her dental degree from Tribhuvan University, Nepal where she topped her class and was a recipient of the 2006 gold medal. Dr. Shrestha worked for two years in academia after graduation and followed her passion to pursue a Masters in Oral Pathology from India in 2008-2011. After working for four years as an Assistant professor in Oral Pathology in Nepal, Dr. Shrestha earned a Japanese government scholarship (MEXT) to pursue her Ph.D. in Japan, where her research in molecular carcinogenesis have received several awards as best paper, poster, young investigator award, etc. in Japan and international meetings. Dr. Shrestha was a recipient of the Dean’s award in 2019 at Hiroshima University. Dr. Shrestha joined Texas A&M University where she completed her Masters in Oral Biology as well as a certificate and fellowship in Oral & Maxillofacial Pathology in 2022. She joined the National Institutes of Dental and Craniofacial Research at the NIH as a clinical fellow for six months before transitioning back as a faculty in her alma mater. Dr. Shrestha has published several peer-reviewed manuscripts and serves on the editorial board of Triple O and Frontiers of Oral Health and as a reviewer of several scientific journals in dentistry and pathology. Her research interests include oral cancer, precancer and molecular carcinogenesis, soft tissue tumors, bone research and salivary gland pathology. Dr. Shrestha served as the Vice President of the Chancellors’ student advisory committee of Texas A&M University and as a CSAC representative from the TAMHSC student governing board. Dr. Shrestha likes writing poems and stories and was a student blog ambassador during her residency. She strives to promote inter-professional collaborations plus research collaborations between international institutions. Her long-term goals are to work in an academic institution and contribute to research in the field of Oral Pathology. Besides her research interest, Dr. Shrestha enjoys experimenting with Nepalese and Japanese dishes, volunteering in social organizations for kids and hiking, and she has a bucket list to climb some of the famous mountains of the world!

Education and Training

National Institutes of Health- Clinical Fellow, 2022
Texas A&M University, Dallas, Texas, M.S (Masters in Oral Biology, 2019-2022
Texas A&M University, Dallas, Texas, , Certificate in Oral & Maxillofacial Pathology, 2019-2022
Hiroshima University, Hiroshima, Japan, Ph. D In Biomedical Sciences (Oral &Maxillofacial pathology), 2015-2019
Manipal College of Dental Sciences, Mangalore, India under Kathmandu University, Nepal, M.D.S (Master of Dental Surgery) in Oral Pathology, 2008-2011
People’s Dental College & Hospital, Nepal, Tribhuvan University, B.D.S (Bachelor of Dental Surgery), 2000-2006

Professional Certifications

2023 Texas Dental Association
2022 Diplomate, American Board of Maxillofacial Pathology
2021 Fellow of the AAOMP
2019 Member, AAOMP
2019 Executive Committee & Founding Member, Nepalese Association of Oral & Maxillofacial Pathologists
2019 Life member, Hiroshima University Faculty of Dentistry Alumni
2014 Member, ASOMP (Asian Society of Oral & Maxillofacial pathology)
2014 International Association of Oral Pathologists
2014 Member, Japanese Society of Oral Pathology (JSOP)
2008 Member, Indian Association of Oral & Maxillofacial Pathologists
2006 Member, Nepal Medical Council
2006 Member, Nepal Dental Association

Research Interests

Oral precancer, cancer and molecular carcinogenesis
Salivary gland pathology
Bone biology and bone diseases
AI in Pathology

Awards, Recognition and Service

2015-2019 MEXT – “Mongbukagakusho” Japanese government scholarship
Deans’ Award, 2019, awarded by the Dean University
2019 Hiroshima University Dental Alumni award, Japan
2018 “Waldron Award”- Best Poster abstract award (international) – Joint meeting of International Association of Oral Pathology and American Academy of Oral & Maxillofacial Pathology, Canada
2018 “Young investigator award”- Hiroshima University, 7th Hiroshima Conference on Education and Science in Dentistry, Hiroshima
2018 Best Poster presentation- Hiroshima University, 7th Hiroshima Conference on Education and Science in Dentistry, Hiroshima
2017 Best Presentation & “Research Incentive Award” at 50th General Meeting of the Hiroshima University Dental Society, Japan
2016 Best Oral Presentation award (International), Joint meeting of 18th International Association of Oral Pathology (IAOP) & 25th IAOMP (Indian Association of Oral & Maxillofacial Pathology), India
2016 Travel grant, 18th IAOP & 25th IAOMP conference, Chennai, India
2016 M.D Anderson Travel grant- for international conference on Betel Quid and Areca, Kuala Lampur, Malaysia
2011 Highest rank- Oral & Maxillofacial Pathology in Post-graduate program, MCODS, Mangalore, India
2010 Best Women Athlete award, Annual sports festival, 2010, MCODS, Mangalore, India
2010 Best paper award- VIIIth Forensic Odontology Conference, S.P.P.G.I.D.M.S, Lucknow, India on 30-10-2010 to 31-10-2010
2006 Gold medal- highest academic excellence in Dental School (B.D.S), Kathmandu, Nepal
1998 School topper certificate- School Leaving Certificate (High School), Itahari, Nepal

Representative Publications

Scientific Articles

Sakamoto, S., Nagasaki, A., Shrestha, M. et al. Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation. Sci Rep 13, 9350 (2023).
Lior Aljadeff, Madhu Shrestha, Roderick Y Kim, Thomas Schlieve, Fayette Williams, John Wright, Daniel Hammer. A slow growing anterior maxillary mass- clinicopathologic case of the month. Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2021, Jan 21(00068-7)
Madhu Shrestha, Mark Glover, Yi- Shing Lisa Cheng. Oral & Maxillofacial pathology case of the month- Case Oral Lichen Planus-Texas Dental Journal, 2019, 136(9):506-509,526-530
Madhu Shrestha, Toshinori Ando, Chanbora Chea, Shinnichi Sakamoto, Takashi Nishisaka, Ikuko Ogawa, Mutsumi Miyauchi, Takashi Takata. The transition of tissue inhibitor of metalloproteinases from -4 to -1 induces aggressive behavior and poor patient survival in dedifferentiated lipo-sarcoma via YAP/TAZ activation, Carcinogenesis, 40(10), 2019, 1288–1297.
Chanbora Chea , Sivmeng Haing, Mutsumi Miyauchi, Madhu Shrestha, Hiromichi Imanaka, Takashi Takata., Molecular mechanisms underlying the inhibitory effects of bovine lactoferrin on osteosarcoma, Biochemical and Biophysical Research Communications, 508(3) 2019, 946-952
Toshinori Ando, Dyshaphilia Charindra, Madhu Shrestha, Ikuko Ogawa, Mutsumi Miyauchi & Takashi Takata. Tissue inhibitor of metalloproteinase-1 promotes cell proliferation through YAP/TAZ activation in cancer. Oncogene37, 263–270 (2018) doi:10.1038/onc.2017.321
Chea C, Miyauchi M, Inubushi T, Febriyanti Ayuningtyas N, Subarnbhesaj A, Nguyen PT, Shrestha M, Haing S, Ohta K, Takata T. Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma. PLoS ONE 13(1): e0191683. (2018)
Toshinori Ando, Madhu Shrestha, Takashi Nakamoto, Kaori Uchisako, Sachiko Yamasaki, Koichi Koizumi, Ikuko Ogawa, Mutsumi Miyauchi & Takashi Takata. A case of primordial odontogenic tumor: A new entity in the latest WHO classification (2017). Pathology international67:365-369.
Nagasaki A, Ogawa I, Sato Y, Takeuchi K, Kitagawa M, Ando T, Sakamoto S, Shrestha M, Uchisako K, Koizumi K, Toratani S, Konishi M, Takata T. (2017): Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report. Pathology International. doi:10.1111/pin.12609
Toshinori Ando, Yasusei Kudo, Shinji Iizuka, Takaaki Tsunematsu, Hanako Umehara, Madhu Shrestha, Toshihiro Matsuo, Tadahiko Kubo, Shouji Shimose, Koji Arihiro, Ikuko Ogawa, Mitsuo Ochi & Takashi Takata. Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma. Scientific Reports. 7, 40187; doi: 10.1038/ srep40187 (2017)
Shrestha M, Srikant N, N Ramsudhan, Shakya A, Comparative Evaluation of two established age estimation techniques (two histological and radiographical) by Image Analysis Software using single tooth. The Open Forensic Science Journal, 2015, 8(1):1-7
Lamichhane RS, Boaz K, Natrajan S, Shrestha M. Assessment of Candidal carriage in patients with Type II Diabetes Mellitus. Journal of Pathology of Nepal (2015) Vol. 5, 733-738
Lamichhane RS, Boaz K, Natrajan S, Shrestha M. A cytomorphometric analysis of the oral mucosa in patients with type II Diabetes Mellitus. Journal of Pathology of Nepal (2015) Vol. 5, 824-833
M Shrestha, P Shakya, S Shrestha. Intraoral cysticercosis of the masseter muscle- a rare finding; correlation of histopathology with MRI and USG. Journal of Chitwan Medical College (2014); 4(8)
Shrestha M, Boaz K, Srikant N, Shakya A. An Assessment of Candidal Colonization and Species Differentiation in Head and Neck Cancer Patients Receiving Radiation. J Nepal Health Res Counc (2014) Sep - Dec;12(28):156-61
A Shakya, M Shrestha, A Srivastav, B Kayastha. Oral health related knowledge, attitude, and practice among school children of Jyamrung, Nepal- Journal of Chitwan Medical College, 2014
A Shakya, A Rao, R Shenoy, M Shrestha. Oral health related knowledge and attitude of anganwadi of Mangalore City, India- Journal of Chitwan Medical College, 2013

Abstracts
P Patel, M Shrestha, S Nelson, V Woo. “metastatic leiomyosarcoma of the palatal gingiva masquerading as a pyogenic granuloma.” Oral surgery, oral medicine, oral pathology and oral radiology. 133.5 (2022): e161–e162.
Shrestha, Madhu et al. “Oncocytic Variant of Mucoepidermoid Carcinoma – A Report of Two Cases and Review of Histopathology, Immunohistochemistry, and Molecular Profiling.” Oral surgery, oral medicine, oral pathology and oral radiology. 133.5 (2022)