Chunlin Qin, PhD, DDS, MS

Biography

Education and Post-Graduate Training

• Postdoctoral Fellow, Department of Basic Sciences, University of Texas Health Science Center at Houston, Dental Branch (1998-2003)
• Ph.D., Department of Oral Pathology, Okayama University Graduate School of Dentistry, Okayama, Japan (1998)
• M.S., Department of Oral and Maxillofacial Surgery, Harbin Medical University School of Dentistry, Harbin, China (1989)
• D.M.D., Harbin Medical University School of Dentistry, Harbin, China (1983)

Career History

• Associate Dean for Research, Texas A&M University-Health Science Center (TAMU-HSC) School of Dentistry, Dallas, USA (2022-Present)
• Professor with tenure, Department of Biomedical Sciences, Texas A&M University College of Dentistry   (2013-present)
• Associate Professor with tenure, Department of Biomedical Sciences, Texas A&M University College of Dentistry (2009-2013)
• Assistant Professor, Department of Biomedical Sciences, Texas A&M University College of Dentistry (2006-2009)
• Assistant Professor, Department of Endodontics, University of Texas Health Science Center at Houston, Dental Branch (2003-2006)
• Visiting Scientist, Department of Oral Pathology, Okayama University School of Dentistry, Okayama, Japan (1993-1994)
• Visiting Scientist, Department of Oral Surgery, Asahi University School of Dentistry, Japan (1992-1993)
• Senior Assistant Professor (Lecturer), Senior Doctor, Department of Oral and Maxillofacial Surgery, Harbin Medical University School of Dentistry, China (1989-1992)
• Assistant Professor, Department of Endodontics & Periodontics, Harbin Medical University School of Dentistry, China (1983-1986)

Teaching Interests

• Teaching responsibilities include Biochemistry/Nutrition (dental), Oral Histology (dental), Cell and Molecular Biology (graduate), and Oral Histology (dental hygiene)
• Currently working on enhancing graduate education in the fundamentals of biomineralization for applications in biomedicine and the environment

Research Interests

The Qin laboratory has been primarily focused on the major projects as follows:

1. One of Dr. Qin’s long-time research focuses is to investigate the roles of the extracellular matrix (ECM), and the non-collagenous proteins (NCPs) in the formation and mineralization of bone, dentin and cementum. Dr. Qin has been focusing on one category of NCPs known as the SIBLING (Small Integrin-Binding LIgand, N-linked Glycoprotein) family, which includes dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP), osteopontin (OPN) and matrix extracellular phosphoglycoprotein (MEPE). The Qin laboratory is seeking to understand the overall processes of osteogenesis, dentinogenesis and cementogenesis by focusing upon the nature, metabolism, tissue/cell localization and functions of DMP1, DSPP, BSP and OPN. In particular, DMP1 and DSPP are proteolytically processed into the NH₂- and COOH-terminal fragments; Dr. Qin’s group has tested and confirmed the hypothesis that the posttranslational processing events of DMP1 and DSPP play crucial roles in the mechanisms governing the formation and mineralization of bone, dentin and cementum.

2. The second focus of Dr. Qin’s research work is to study the biological roles of FAM20 (Family with sequence similarity 20) members, which include FAM20A, FAM20B and FAM20C. FAM20C is a kinase that phosphorylates many non-collagenous proteins in the mineralized tissues. Mutations in the human FAM20C gene are associated with the hereditary disease known as Raine syndrome. Dr. Qin’s studies on FAM20C have shown that this kinase plays critical roles in biomineralization and regulation of total body phosphorus homeostasis.

3. The third focus of Dr. Qin’s group is to study the nature, tissue/cell localization and functions of bone morphogenetic protein 1 (BMP1) and tolloid-like 1 (TLL1), two proteases that play important roles in the cleaving/activating secretory proteins. Dr. Qin’s group discovered the deletion of Bmp1 and Tll1 in the type I collagen-expressing cells lead to dentin and periodontal defects in mice.

Recent Grants

• Functions of Family with Sequence Similarity 20 - Member C (FAM20C) and Member A (FAM20A) in Amelogenesis and Dentinogenesis. NIH/NIDCR R01 DE030081-01; 09/14/2022-08/31/2025 (PI)

• Dentin Sialophosphoprotien (DSPP) and Unfolded Protein Response (UPR) in Dentinogenesis Imperfecta (DGI) and Odontoblast Function. NIH/NIDCR R01 DE027345-01A1; 07/30/2018-05/31/2025 (PI)

• Multifunctional Ionic Liquids Coatings for Dental Implant Surfaces. NIH/National Institute of Dental and Craniofacial Research. NIH/NIDCR R01 DE026736; 07/14/2017-08/31/2022 (Consultant)

• Studies of Proteins Involved in Dentinogenesis. NIH/NIDCR  R01 DE005092:27-31; 07/01/04-06/30/09 (PI)

• Studies of Proteins Involved in Dentinogenesis. NIH/NIDCR  R01 DE005092-31 Supplement, 06/01/09-05/31/10 (PI)

• Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis.  NIH/NIDCR R01 DE005092: 32-35, 07/01/09-06/30/14 (PI)

• Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis. NIH/NIDCR R01 DE005092-32A1S1 (American Recovery and Reinvestment Act of 2009-Grant), 09/23/09-08/31/11 (PI) 

• Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis.  NIH/NIDCR R01 DE005092-32A1S2; 03/31/10-08/31/11 (PI) 

• The Roles of FAM20C (DMP4) in Odontogenesis and Osteogenesis.  NIH/NIDCR R01 DE022549-01A1:1-5; 12/01/12-11/30/17 (PI)

Selected Publications

1. Siddiqui MF, Li J, Wang S, Zhang H, Qin C. Lu Y: FAM20A is a Golgi-localized Type II transmembrane protein. Scientific Reports, 14: 6518. 2024
2. Xu X, Li J, Zhang H, Wang S, Qin C, Lu Y: Constitutive expression of spliced X-box binding protein 1 inhibits dentin formation in mice. Front Physiol.  14: 1319954. 2023
3. Zhang H, Lu Y, Kramer P, Benson MD, Cheng YL, Qin C: Intracranial calcification in Fam20c-deficient mice recapitulates human Raine syndrome. Neurosci Lett. 802:137176. 2023
4. Lyu H, Zhou X, Qian Y, Liu X, Gopinathan G, Pandya M, Qin C, Luan X, Diekwisch T: “Long-acting PFI-2 small molecule release and multilayer scaffold design achieve extensive new formation of complex periodontal tissues with unprecedented fidelity.” Biomaterials. 290: 121819. 2022
5. Barnts K, Feng JQ, Qin C, Zhang H, Cheng YL: Adenomatoid Odontogenic Tumor: Evidence for a Mixed Odontogenic Tumor. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 133: 675–683.  2022
6. Huang Y, Chen H, Zhang H, Lu Y, Qin C: FAM20C plays a critical role in the development of mouse vertebra. Spine J. 22: 337–348, 2022
7. Liang T, Xu Q, Zhang H, Wang S, Diekwisch T, Qin C, Lu Y: Enamel defects associated with dentin sialophosphoprotein mutation in mice. Front Physiol. 12: 724098, 2021
8. Zhang H, Xu Q, Lu Y, Qin C: High phosphate diet improved the formation of dentin in Fam20c-deficient mice. Eur J Oral Sci. 129:e12795, 2021
9. Xu Q, Zhang H, Wang S, Qin C, Lu Y: Constitutive Expression of Spliced XBP1 Causes Perinatal Lethality in Mice. Genesis. 59:e23420, 2021
10. 10.Jani P, Zhang H, Benson D, Qin C: Noggin inhibition of mouse dentinogenesis. J Oral Biosci; 62:72-79, 2020.
11. 11.Zhang H, Li l, Lu Y, Qin C: High phosphate diet improved the skeletal development of Fam20C-deficient mice. Cells Tissues Organs. 208:25-36, 2020.
12. 12.Li L, Saiyin W, Zhang H, Wang S, Xu Q, Qin C, Lu Y: FAM20A is essential for amelogenesis, but is dispensable for dentinogenesis. J Mol Histol. 50:581-591, 2019
13. 13.Saiyin W, Li L, Zhang H, Lu Y, Qin C: Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF-β and MAPK signaling pathways. Biochim Biophys Acta Mol Basis Dis. 1865:165555. 2019
14. 14.Miao N, Zhan Y, Xu Y, Yuan H, Qin C, Lin F, Xie X, Mu S, Yuan M, Mu H, Guo S, Li Y, Zhang B: Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice. Int J Mol Med. 43:2103-2117, 2019
15. 15.Liang T, Zhang H, Xu Q, Wang S, Qin C, Lu Y: Mutant Dentin Sialophosphoprotein Causes Dentinogenesis Imperfecta. J Dent Res. 98:912-919, 2019
16. 16.Liu X, Li N, Zhang H, Liu J, Zhou N, Ran C, Chen X, Lu Y, Wang X, Qin C, Xiao J, Liu C: Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects. Eur J Oral Sci. 126:433-436, 2018
17. 17.Zhang H, Xie X, Liu P, Liang T, Lu Y, Qin C: Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice. PLoS One 13:e0195854, 2018
18. Liu C, Zhou N, Wang Y, Zhang H, Jani P, Wang X, Lu Y, Li N, Xiao J, Qin C: Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells. Exp Cell Res. 363:188-195, 2018
19. Jani P,  Liu C, Zhang H, Younes K, Benson MD, Qin C: The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis. Arch Oral Biol. 90:33-39, 2018
20. Liu C, Zhang H, Jani P, Wang X, Lu Y, Li N, Xiao J, Qin C: FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner. J Cell Physiol. 233:3476-3486, 2018
21. Jiang C, Zurick K, Qin C, Bernards MT: Probing the influence of SIBLING proteins on collagen-I fibrillogenesis and denaturation. Connect Tissue Res. 59:274-286, 2018
22. Yan W, Ma P, Tian Y, Wang J, Qin C, Feng J, Wang X: The importance of a potential phosphorylation site in enamelin on enamel formation. Int J Oral Sci. 9:e4, 2017
23. Zhang H, Jani P, Liang T, Lu Y, Qin C: Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of Molecular Histology. 48:83-98, 2017.
24. Liu P, Ma S, Zhang H, Liu C, Lu Y, Chen L, Qin C: Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia. Sci Rep. 7:3590, 2017.
25. Arnold P, Koopmann L, Peters F, Birkenfeld F, Goff SV, Damm T, Qin C, Moali C, Lucius R, Becker-Pauly C: Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice. Cell Tissue Res. Cell and Tissue Research. 367:351-358, 2017.
26. Zhang H, Liu P, Wang S, Liu C, Jani P, Lu Y, Qin C: Transgenic expression of dentin phosphoprotein inhibits skeletal development. Eur J Histochem. 60:2587, 2016.
27. Li L, Liu P, Xie X, Ma S, Liu C, Chen L, Qin C: Loss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowth. Int J Oral Sci. 8:98-109, 2016
28. Jani PH, Gibson MP, Liu C, Zhang H, Wang X, Lu Y, Qin C: Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix Biol. 52-54:95-112, 2016.
29. Xie X, Liu C, Zhang H, Jani PH, Lu Y, Wang X, Zhang B, Qin C: Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression. Sci Rep. 6:25364, 2016.
30. Ma S, Liu W, Liu P, Liu J, Chen L, Qin C: Tanshinone IIA treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A. J Periodont Res. 51:567-576, 2016.
31. Verdelis K, Szabo-Rogers H, Xu Y, Chong R, Kang R, Cusack B, Jani P, Boskey A, Qin C, Beniash E:  Accelerated Enamel Mineralization in Dspp mutant mice. Matrix Biol. 52-54:246-259, 2016.
32. Nurrohman H, Saeki K, Carneiro K, Chien Y, Djomehri S, Ho S, Qin C Marshall S, Gower L, Marshall G, Habelitz S: Repair of dentin defects from DSPP knockout mice by PILP mineralization. J Mater Res. 31:321-327, 2016.
33. Ma P, Yan W, Tian Y, Wang J, Feng JQ, Qin C, Cheng YS, Wang X. Inactivation of Fam20B in joint cartilage leads to chondrosarcoma and postnatal ossification defects. Sci Rep. 6:29814, 2016.
34. Liang T, Meng T, Wang S, Qin C, Lu Y: The LPV Motif is Essential for the Efficient Export of Secretory DMP1 from the Endoplasmic Reticulum. J Cell Physiol. 231:1468-1475, 2016.
35. Tian Y, Ma P, Liu C, Yang X, Crawford DM, Yan W, Bai D, Qin C, Wang X: Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors.  Eur J Oral Sci. 123:396-402, 2015
36. Meng T, Huang Y, Wang S, Zhang H, Dechow PC, Wang X, Qin C, Shi B, D'Souza RN, Lu Y: Twist1 is Essential for Tooth Morphogenesis and Odontoblast Differentiation. J Biol Chem. 290:29593-29602, 2015.
37. Wu W, Gu S, Sun C, He W, Xie X, Li X, Ye W, Qin C, Chen Y, Xiao J, Liu C: Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves. PLoS One.10:e0136951, 2015.
38. Fujikawa K, Yokohama-Tamaki T, Morita T, Baba O, Qin C, Shibata S: An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.  Eur J Histochem. 59:e2553, 2015.
39. Feng J, Zhang H, Qin C: Letter to the Editor, "Osterix Regulates Tooth Root Formation in a Site-specific Manner". J Dent Res.  94:1326, 2015.
40. Mobley C, Kuzynski M, Zhang H, Jani P, Qin C, Napierala D: Dspp-independent effects of transgenic Trps1 overexpression on dentin formation. J Dent Res. 94:1128-1134, 2015
41. Liu C, Wang X, Zhang H, Xie X, Liu P, Liu Y, Jani PH, Lu Y, Chen S, Qin C: The immortalized mouse floxed Fam20c dental papillar mesenchymal and osteoblast cell lines retain their primary genotypes and phenotypes. Journal of Cellular Physiology. 230:2581-2587, 2015.
42. Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, Qin C, Ke H, Liu M, Feng JQ: Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model. FASEB J. 29:2702-2711, 2015.
43. Du E, Wang X, Yang W, Kaback D, Yee S, Qin C, George A, Hao J: Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice. International Journal of Oral Science. 7:89-94, 2015.
44. Zhang H, Jiang Y, Sunita PH, Liu Y, Qin C, Feng JQ: Essential role of Osterix for tooth root but not crown dentin formation. J Bone Miner Res. 30:742-746, 2015.
45. Wang X, Wang J, Liu Y, Yuan B, Ruest LB, Feng JQ, Qin C: The specific role of FAM20C in dentinogenesis. J Dent Res. 94:330-336, 2015.
46. Liu P, Zhang H, Liu C, Wang X, Chen L, Qin C: Inactivation of FAM20C in cells expressing Type I collagen causes periodontal disease in mice. PLoS One. 9:e114396, 2014.
47. Gibson MP, Jani P, Wang X, Lu Y, Qin C: Overexpressing the NH₂-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice. Journal of Oral Biosciences. 56:143-148, 2014.
48. Ma S, Liu P, Li Y, Hou L, Chen L, Qin C: Cyclosporine A Inhibits Apoptosis of Rat Gingival Epithelium.  J Periodontol. 85:1126-1134, 2014.
49. Huang Y, Meng T, Wang S, Zhang H, Mues G, Qin C, Feng JQ, D'Souza RN, Lu Y: Twist1- and Twist2-haploinsufficiency results in reduced bone formation. PLoS One. 9:e99331, 2014.
50. Xie X, Ma S, Li C, Liu P, Wang H, Chen L, Qin C: Expression of small integrin-binding ligand N-linked glycoproteins (SIBLINGs) in the reparative dentin of rat molars. Dental Traumatology 30:285-295, 2014.
51. Wang X, Wang J, Yuan B, Lu Y, Feng JQ, Qin C: Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice. Connect Tissue Res. 55:299-303, 2014.
52. Lin S, Zhang Q, Cao Z, Lu Y, Zhang H, Yan K, Liu Y, McKee MD, Qin C, Chen Z, Feng JQ: Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. J Biol Chem. 289:21533-21543, 2014.
53. Wang X, Jung J, Liu Y, Yuan B, Lu Y, Feng J, Qin C: The specific role of FAM20C in amelogenesis. J Dent Res. 92:995-999, 2013
54. Liu Q, Gibson MP, Sun H, Qin C: Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage. J Histochem Cytochem. 61:749-758, 2013
55. Gibson MP, Jani P, Liu Y, Wang X, Lu Y, Feng J, Qin C: Failure to process dentin sialophosphoprotein (DSPP) into fragments leads to periodontal defects in mice. Eur J Oral Sci. 121:545-550, 2013
56. Gibson MP, Zhu Q, Liu Q, D’Souza R, Feng J, Qin C: Loss of DSPP leads to periodontal disease in mice. J. Periodontal Res. 48:221-227, 2013
57. Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng JQ, Qin C: Role of the NH₂-terminal fragment of dentin sialophosphoprotein in dentinogenesis. Eur J Oral Sci. 121:76-85, 2013
58. Gibson MP, Zhu Q, Wang S, Liu Q, Liu Y, Wang X, Yuan B, Ruest LB, Feng JQ, D'Souza RN, Qin C (co-corresponding author), Lu Y: The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. J Biol Chem. 288:7204-7214, 2013
59. Sun Y, Jiang Y, Liu Q, Gao T, Feng JQ, Dechow P, D'Souza RN, Qin C, Liu X: Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration. Tissue Eng Part A. 19:1754-1763, 2013
60. Shibata S, Sakamoto Y, Baba O, Qin C, Murakami G, Cho BH (2013): An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses. Eur J Histochem. 57:e39, 2013
61. Li C, Xie X, Wang X, Sun Y, Liu P, Chen L, Qin C: Differential expression and localization of dentin matrix protein 1 (DMP1) fragments in mouse submandibular glands. J Mol Histol. 44:231-239, 2013. 
62. Zurick KM, Qin C, Bernards MT: Mineralization induction effects of osteopontin, bone sialoprotein, and dentin phosphoprotein on a biomimetic collagen substrate. J Biomed Mater Res A. 101:1571-1581, 2013
63. Zhu Q, Gibson MP, Liu Q, Liu Y, Lu Y, Wang X, Feng JQ, Qin C: Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis. J Biol Chem.  287:30426-30435, 2012
64. Wang X, Wang S, Lu Y, Gibson MP, Liu Y, Yuan B, Feng JQ, Qin C: FAM20C plays an essential role in the formation of murine teeth. J Biol Chem. 287:35934-35942, 2012
65. Siyam A, Wang S, Qin C, Mues G, Stevens R, D'Souza R, Lu Y: Nuclear localization of DMP1 proteins suggests a role in intracellular signaling. Biochem Biophys Res Commun.   , 2012
66. Rangiani A, Cao ZG, Liu Y, Voisey Rodgers A, Jiang Y, Qin C, Feng JQ: Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation. Int J Oral Sci. 4:189-195, 2012.
67. Zurick KM, Qin C, Bernards MT. Adhesion of MC3T3-E1 cells bound to dentin phosphoprotein specifically bound to collagen type I. J Biomed Mater Res A. 100: 2492-2498, 2012.
68. Rangiani A, Cao Z, Sun Y, Lu Y, Gao T, Yuan B, Rodgers A, Qin C, M Kuro-o M, Feng JQ: Protective roles of DMP1 in high phosphate homeostasis. PLoS One. 7: e42329, 2012
69. Zhu Q, Prasad M, Kong H, Lu Y, Sun Y, Wang X, Yamoah A, Feng JQ, Qin C: Partial blocking of mouse DSPP processing by substitution of Gly⁴⁵¹-Asp⁴⁵² bond suggests the presence of secondary cleavage site(s). Connect Tissue Res. 53: 307-312, 2012
70. Napierala D, Sun Y, Maciejewska I, Bertin TK, Dawson B, D'Souza R, Qin C, Lee B: Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype of Colla1-Trps1 transgenic mice. J Bone Miner Res. 27:1735-1745, 2012
71. Wang X, Wang S, Li C, Gao T, Liu Y, Rangiani A, Sun Y, Hao J, George A, Lu Y, Groppe J, Yuan B, Feng JQ, Qin C: Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS Genet. 8: e1002708, 2012.
72. Qin Q, Xu Y, He T, Qin C, Xu J: Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Res. 22:90-106, 2012.
73. Prasad M, Zhu Q, Sun Y, Wang X, Kulkarni A, Boskey A, Feng JQ, Qin C: Expression of dentin sialophosphoprotein in non-mineralized tissues. J Histochem Cytochem. 59:1009-21, 2011.
74. Sun Y, Chen L, Ma S, Zhou J, Feng JQ, Qin C: Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis. Cells Tissues Organs. 194:199-204, 2011
75. Sun Y, Lu Y, Chen L, Gao T, D'Souza R, Feng JQ, Qin C. DMP1 Processing is Essential to Dentin and Jaw Formation. J Dent Res. 90:619-624, 2011
76. Zhang R, Lu Y, Ye L, Yuan B, Yu S, Qin C, Xie Y, Gao T, Drezner MK, Bonewald LF, Feng JQ: Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. J Bone Miner Res. 26:1047-1056, 2011
77. Shi J, Song T, Jiao X, Qin C, Zhou J. Single-nucleotide polymorphisms (SNPs) of the IRF6 and TFAP2A in non-syndromic cleft lip with or without cleft palate (NSCLP) in a northern Chinese population. Biochem Biophys Res Commun. 410:732-736, 2011
78. Ma D, Zhang R, Sun Y, Rios HF, Haruyama N, Han X, Kulkarni AB, Qin C, Feng JQ:  A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem. 286:4302-4309, 2011
79. Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF, Feng JQ: The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. J Bone Miner Res.  26:331-340, 2011
80. Sun Y, Prasad M, Gao T, Wang X, Zhu Q, D'Souza R, Feng JQ, Qin C: Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. J Biol Chem. 285:31713-31722, 2010
81. Jiang B, Cao Z, Lu Y, Janik C, Lauziere S, Xie Y, Poliard A, Qin C, Ward LM, Feng JQ: DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. J Bone Miner Res. 25:2155-2164, 2010
82. Zhu Q, Sun Y, Prasad M, Wang X, Yamoah AK, Li Y, Feng J, Qin C: Glycosaminoglycan chain of dentin sialoprotein proteoglycan. J Dent Res. 89:808-812, 2010
83. Sun Y, Lu Y, Chen S, Prasad M, Wang X, Zhu Q, Zhang J, Ball H, Feng J, Butler WT, Qin C: Key proteolytic cleavage site and full-length form of DSPP. J Dent Res.  89:498-503, 2010
84. Sun Y, Ma S, Zhou J, Yamoah AK, Feng JQ, Hinton RJ, Qin C: Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the articular cartilage of the rat femoral head. J Histochem Cytochem. 58:1033-1043, 2010
85. Wang X, Hao J, Xie Y, Sun Y, Hernandez B, Yamoah AK, Prasad M, Zhu Q, Feng JQ, Qin C: Expression of FAM20C in the osteogenesis and odontogenesis of mouse. J Histochem Cytochem. 58:957-967, 2010
86. Zhang B, Sun Y, Chen L, Guan C, Guo L, Qin C: Expression and distribution of SIBLING proteins in the predentin/dentin and mandible of hyp mice. Oral Dis. 16:453-464, 2010
87. Sun Y, Gandhi V, Prasad M, Yu W, Wang X, Zhu Q, Feng JQ, Hinton RJ, Qin C: Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible. Int J Oral Maxillofac Surg. 39:272-281, 2010
88. Prasad M, Butler WT, Qin C: Dentin sialophosphoprotein in biomineralization. Connect Tissue Res. 51:404-417, 2010
89. Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT, Boskey AL: Different forms of DMP1 play distinct roles in mineralization. J Dent Res. 2010, 89:355-359, 2010
90. Lv K, Huang H, Lu Y, Qin C, Li Z, Feng JQ: Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus. Int J Biol Sci. 6:537-545, 2010
91. Shi J, Jiao X, Song T, Zhang B, Qin C, Cao F: CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population. Eur J Oral Sci. 118:430-433, 2010
92. Maciejewska I, Cowan C, Svoboda K, Butler WT, D'Souza R, Qin C: The NH₂-terminal and COOH-terminal Fragments of Dentin Matrix Protein 1 (DMP1) Localize Differently in the Compartments of Dentin and Growth Plate of Bone. J Histochem Cytochem. 57:155-166, 2009 
93. Lin Y, Cheng YS, Qin C, Lin C, D'Souza R, Wang F: FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors. Dev Dyn. 238:324-330, 2009
94. Maciejewska I, Qin D, Huang B, Sun Y, Mues G, Svoboda K, Bonewald LF, Butler WT, Feng J, Qin C: Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells. Cells Tissues Organs. 189:186-191, 2009
95. Peng T, Huang B, Sun Y, Lu Y, Bonewald LF, Chen S, Butler WT, Feng J, D’Souza RN, Qin C: Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells Tissues Organs. 189:192-197, 2009
96. Lu Y, Qin C, Xie Y, Bonewald LF, Feng JQ: Studies of the DMP1 57-kDa Functional Domain both in vivo and in vitro. Cells Tissues Organs. 189:175-185, 2009
97. Chen S, Chen L, Jahangiri A, Chen B, Wu Y, Chuang H, Qin C, MacDougall M:  Expression and process of small integrin-binding ligand N-linked glycoproteins in mouse odontoblasts. Arch Oral Biol, 53:879-889, 2008
98. Huang B, Maciejewska I, Sun Y,  Peng T, Qin D, Bonewald L, Butler WT, Feng J, Qin C:  Full-length dentin matrix protein 1 in dentin and bone. Calcif Tissue Int. 82: 401-410, 2008
99. Bernards MT, Qin C (co-corresponding author), Jiang S (co-corresponding author): MC3T3-E1 cell adhesion to hydroxyapatite with adsorbed bone sialoprotein, bone osteopontin, and bovine serum albumin. Colloids Surf B Biointerfaces. 64: 236-247, 2008
100. 100.Huang B, Sun Y, Maciejewska I, Qin D, Peng T, Mclntyre B, Wygant J,  Butler WT, Qin C:  Distribution of SIBLING proteins in the organic and inorganic phases of rat dentin and bone.  Eur J Oral Sci. 116: 104-112, 2008
101. 101.Yao Z, Xiang L, Qin C, Schwarz EM, Boyce BF: Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an IL-1-mediated autocrine mechanism. J Biol Chem. 283: 9917-9924, 2008 
102. 102.Bernards MT, Qin C, Ratner BD, Jiang S (co-corresponding author): A comparison of the MC3T3-E1 adhesion properties of bone sialoprotein and bone osteopontin specifically bound to collagen I.  J Biomed Mater Res A. 86:779-787, 2008
103. 103.Shibata S, Baba O, Oda T, Tamaki T,  Qin C, Butler T, Sakakura Y, Takano Y: An immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice. Arch Oral Biol. 53:220-230. 2008
104. 104.Qin C, D’Souza R, Feng J: Dentin Matrix Protein 1 (DMP1): New and Important Roles for Biomineralization and Phosphate Homeostasis. J Dent Res. 86: 1134-1141, 2007
105. 105.Gajjeraman S, Narayanan K, Hao J, Qin C, George A:  Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. J Biol Chem. 282:1193-1204, 2007
106. 106.Liu L, Qin C, Butler WT, Ratner BD, Jiang S: Controlling the orientation of bone osteopontin via its specific binding with collagen I to modulate osteoblast adhesion. J Biomed Mater Res A. 80:102-110, 2007
107. 107.Qin C, Huang B, Wygant JN, McIntyre BW, McDonald CH, Cook RG, Butler WT:  A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH₂-terminal fragment. J Biol Chem. 281:8034-8040, 2006
108. 108.Moses KD, Butler WT, Qin C: Immunohistochemical study of small integrin-binding ligand, N-linked glycoproteins in reactionary dentin of rat molars at different ages. Eur J Oral Sci. 114:216-222, 2006
109. 109.He G, Gajjeraman S, Schultz D, Cookson D, Qin C, Butler WT, Hao J, George A: Spatially and temporally controlled biomineralization is facilitated by interaction between self-assembled dentin matrix protein 1 and calcium phosphate nuclei in solution. Biochemistry. 44:16140-16148, 2005
110. 110.Qin C, Baba O, Brunn JC, McKee MD, Bonewald L, Butler WT:  Dentin Matrix Protein 1 (DMP1) and Dentin Sialophosphoprotein (DSPP) Share Unique Properties Including Tissue Localization, Proteolytic Processing, and High Molecular Weight Forms. In: Sodek J, Landis W, ed. Proceedings of the 8th ICCBMT. Banff, Alberta, Canada: University of Toronto Press, 2005; pp 174-177, 2005
111. 111.Baba O, Qin C, Brunn JC, Bonewald L, Terashima T, Butler WT:  Immunolocalization of dentin matrix protein 1 (DMP1) fragments in developing rat molar. In: Sodek J, Landis W, ed. Proceedings of the 8th ICCBMT. Banff, Alberta, Canada: University of Toronto Press, pp 143-146, 2005
112. 112.Boskey AL, Spevak L, Fujimoto Y, Silverman L, Qin C, Brunn JC, Butler WT:  High thoughout screening of proteins involved in biomineralization suggests role for α₂-HS glycoprotein. In: Sodek J, Landis W, ed. Proceedings of the 8th ICCBMT. Banff, Alberta, Canada: University of Toronto Press, pp 224-226, 2005
113. 113.Gericke A, Qin C, Spevak L, Fujimoto Y, Butler WT, Sorensen ES, Boskey AL: Importance of  phosphorylation for osteopontin regulation of biomineralization. Calcif Tissue Int. 77:45-54, 2005
114. 114.Young CS, Kim SW, Qin C, Baba O, Butler WT, Taylor RR, Vacanti JP, Bartlett JD, Yelick PC: Developmental analysis and computer modelling of bioengineered teeth. Arch Oral Biol. 50:259-265, 2005
115. 115.Qin C, Baba O and Butler WT: Posttranslational modifications of SIBLING proteins and their roles in osteogenesis and dentinogenesis. Crit Rev Oral Biol Med. 15:126-136, 2004 
116. 116.Baba O, Qin C*, Brunn JC, Wygant JN, McIntyre BW, Butler WT: Co-localization of dentin matrix protein 1 (DMP1) and dentin sialoprotein (DSP) at late stages of rat molar development. Matrix Biol. 23:371-379, 2004 (*corresponding author)
117. 117.Baba O, Qin C, Brunn JC, Jones JE, Wygant JN, McIntyre BW, Butler WT: Detection of dentin sialoprotein (DSP) in periodontium. Eur J Oral Sci. 112:163-170, 2004
118. 118.Tartaix PH, Doulaverakis M, George A, Fisher LW, Butler WT, Qin C, Salih E, Tan M, Fujimoto Y, Spevak L, Boskey AL: Dentin matrix protein-1: In vitro effects on hydroxyapatite formation provide insights into in vivo functions. J Biol Chem. 279:18115-18120, 2004
119. and cleavage sites. J Biol Chem. 278:34700-34708, 2003
120. 120.Qin C, Brunn JC, Baba O, Wygant JN, McIntyre BW, Butler WT: Dentin sialoprotein isoforms: detection and characterization of a high molecular weight dentin sialoprotein (HMW-DSP). Eur J Oral Sci. 111:235-242, 2003
121. 121.Qin C, Brunn JC, Cadena E, Ridall A, Butler WT: Dentin sialoprotein in bone and dentin sialophosphoprotein gene expressed by osteoblasts. Conn Tissue Res. 44:179-183, 2003
122. 122.Butler WT, Brunn JC, Qin C: Extracellular matrix (ECM) proteins: Comparison to bone and contribution to dynamics of dentinogenesis. Conn Tissue Res. 44:171-178, 2003
123. 123.Qin C, Brunn JC, Cadena E, Ridall A, Tsujigiwa H, Nagatsuka H, Nagai N and Butler WT: The expression of dentin sialophosphoprotein gene in bone. J Dent Res. 81:392-394, 2002
124. 124.Razzouk S, Brunn JC, Qin C, Tye C, Goldburg HA, Butler WT: Osteopontin post-translational modifications, possibly, phosphorylation is required for in vitro bone resorption but not osteoclast adhesion. Bone. 30:40-47, 2002
125. 125.Butler WT, Brunn JC, Qin C, McKee MD: Extracellular matrix (ECM) proteins and the dynamics of dentin formation. Conn Tissue Res. 43:301-307, 2002
126. 126.Qin C, Cook RG, Orkiszewski RS, Butler WT: Identification and characterization of the corboxy-terminal region of rat dentin sialoprotein (DSP). J Biol Chem 276:904-909, 2001
127. 127.Qin C, Brunn JC, Jones J, George A, Ramachandran A, Gorski JP, Butler WT: A comparative study of sialic acid-rich proteins in rat bone and dentin. Eur J Oral Sci. 109:133-141, 2001
128. 128.Nagai N, Qin C, Nagatsuka H, Inoue M, Ishiwari Y: Age effects on ectopic bone formation induced by purified bone morphogenetic protein. Int J Oral Maxillofac Surg 28:143-150, 1999
129. 129.Qin C, Murata M, Nagatsuka H, Inoue M, Nagai N: Aging and ectopic bone formation induced by partially purified bone morphogenetic protein. Jpn J Oral Biol. 39:352-362, 1997
130. 130.Qin C, Nakano K, Ishiwari Y, Nagai N:  Aging and ectopic bone formation induced by partially purified bone morphogenetic protein: Blood vessel ingrowth and localization of type I collagen and osteocalcin assessed by immunohistochemistry.  J Hard Tissue Biol. 6:95-104, 1997
131. 131.Qin C, Murata M, Nagatsuka H, Kuroda K, Nagai N: Morphological and immunohistochemical study of ectopic bone formation induced by crude BMP in 4-week and 6-month old rats.  J Jpn Soc Oral Implant.  10:288-295, 1997.
132. 132.Qin C, Murata M, Ionue M, Nagatsuka H, Akagi T, Nagai N:  Comparative study of heterotopic bone formation induced by BMP in adult and young rats.  Proceedings of the Fourth International Congress on Oral Cancer, Gifu, Japan pp 229-232.  1995.
133. 133.Qin C, Pan YL, Hashimura J, Takai Y, Yamada T, Mori M: Destructive process of salivary gland parenchyma and development of epimyoepithelial islands assessed by immunohistochemistry. Arch Anat Cytol Pathol. 42:16-25, 1994
134. 134.Mori M, Shrestha P, Sakamoto F, Yang LJ, Qin C, Tsujimura T: Histogenesis and possible mechanism of chondroid changes in mixed tumor of the skin: Immunohistochemical evaluation of bone morphogenetic protein, glycosaminoglycans, keratin, vimentin and neuronal marker. Arch Dermatol Res. 286:285-292, 1994
135. 135.Shrestha P, Yang LJ, Liu BL, Namba M, Qin C, Isono K, Tsukitani K, Mori M: Clear cell carcinomas of salivary glands: Immunohistochemical evaluation of clear tumor cells. Anticancer Res. 14:825-836, 1994
136. 136.Yang LJ, Liu BL, Qin C, Hashimura K, Yamada T, Sumitomo S, Mori M: Comparison of proliferating cell nuclear antigen index in benign and malignant salivary pleomorphic adenoma. Eur J Cancer B Oral Oncol. 30B:50-60, 1994
137. 137.Yang LJ, Hashimura K, Qin C, Shrestha P, Sumitomo S, Mori M: Immunoreactivity of proliferating cell nuclear antigen in salivary gland tumors: An assessment of growth potential. Virchows Arch A Pathol Anat Histopathol. 422:481-486, 1993

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