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Yi-Shing Lisa Cheng, Head

Yi-Shing Lisa Cheng
Yi-Shing Lisa Cheng, DDS, MS, PhD

Professor & Department Head, Diagnostic Sciences

Contact

Department of Diagnostic Sciences
3302 Gaston Ave.
Dallas, TX 75246
ycheng@tamu.edu
Phone: 214.828.8912
Fax: 214.828.8306

Biography

Education and Post-Graduate Training

  • Texas A&M University System Health Science Center - Baylor College of Dentistry, Oral and Maxillofacial Pathology, Dallas, ; Certificate in Oral Pathology; 1999-2002
  • Baylor University, Waco, Texas; PhD; Biomedical Studies 1995-1999;
  • Baylor University, Waco, Texas; MS; Biomedical Studies 1993-1995;
  • China Medical University, School of Dentistry, Taiwan; Residency 1990-1993;
  • Kaohsiung Medical University, School of Dentistry, Kaohsiung, Taiwan; DDS; 1984-1990

Research Interests

Research Grants

  • “Endogenous Fluorescence Lifetime Endoscopy for Early Detection of Oral Cancer and Dysplasia”. ($2,523,823, Feb 2, 2018 – Jan 31, 2023). Co-investigator; funded by National Cancer Institute. 1R01CA218739-01A1
  • “Novel computer aided diagnosis system for early detection of oral cancer based on quantitative autofluorescence imaging”. ($897,394, June 1, 2018 – May 30, 2021). Co-investigator; funded by Cancer Prevention and Research Institute of Texas. RP180588
  • “Chemoablation of High-Risk Oral Premalignant Lesions for Sustained Cancer Prevention” ($915,000, Aug 16, 2017 – Aug 15, 2020). Co-investigator; funded by Cancer Prevention and Research Institute of Texas. RP170179     
  • “Metabolomic Salivary Biomarkers for Oral Cancer Detection”. ($199.999, July 1, 2015-November 30, 2017). Principal Investigator, funded by Cancer Prevention and Research Institute of Texas. RP150703
  • “Novel Pharmacotherapeutic Bioadhesive Patch for Oral Ulcerations”($149,791, August 1, 2014- July 31, 2015) Consultant, funded by NIDCR Small Business Technology Transfer Program. 1R41 DE024343-01. Principal Investigator: Xiaohua Liu, Post Oak Pharmaceutical
  • “Validation of microRNA-27b as a potential salivary biomarker for early oral cancer detection.”($50,000, August 1, 2013- July 31, 2014 )Principal Investigator, funded by Texas A&M Health Science Center, Office of the Vice President for Research, Faculty Bridge Grant.
  • “Does chronic periodontitis affect salivary biomarkers for oral cancer detection?”($50,000, August 1, 2012- July 31, 2013) Principal Investigator, funded by Texas A&M Health Science Center, Office of the Vice President for Research, Faculty Bridge Grant.
  • “Salivary biomarkers for oral cancer in lichen planus patients”. ($381,086, May 1, 2009-April 30, 2012)Principal Investigator, funded by National Institute of Dental and Craniofacial Research, Exploratory and Developmental Grant. 1R21DE018757-01A2
  • “Multiresolution FLIM and Reflectance Confocal Microscopy to Detect Dysplasia” ($ 1,561,662, December 10, 2009 – November 30, 2014)Co-investigator, funded by National Institute of Dental and Craniofacial Research.R01CA138653 - 01A2
  • “Fullerene-based photosensitizers for PDT of dysplastic oral keratinocytes.” ($141,414, July 15, 2007-August 31,2008) Subcontractor/Co-PI, funded by National Institute of Dental and Craniofacial Research, Small Business Innovation Research Program. 1R43DE018070-01
  • “The role of FGFR2(IIIb) in ameloblast differentiation during tooth development.” ($15,000, February 1, 2007-January 31, 2008) Collaborator, funded by Vice President for Research Development Grant, Texas A&M University Health Science Center.
  • “New nanoparticles for antimicrobial therapy of dental plaque related diseases.” ($145,998, August 1, 2006-January 31, 2007) Subcontractor, funded by National Institute of Dental and Craniofacial Research, Small Business Innovation Research Program. 1R43DE017505-01
  • “E-cadherin and snail messenger RNA expression in tobacco associated oral lesions.” ($10,000, June 1, 2005-June 1, 2007) Principal Investigator, funded by Clay Weed Memorial Cancer Fund Trust, Texas
  • “Smad pathway in oral submucous fibrosis.” ($2,340, 9/1/2003-9/1/2004) Co-investigator, funded by National Science Council, Taiwan
  • “Aromatase expression in oral mucosa and squamous cell carcinoma.” ($10,000, 10/1/02-9/30/04).  Principal Investigator, funded by Clay Weed Memorial Cancer Fund Trust, Texas
  • New faculty start-up fund. ($10,000, 4/16/02). Principal Investigator, Funded by Texas A&M University College of Dentistry, Dallas,Texas
  • “Identification of target antigens in oral pemphigoid.” ($3,727.92, 5/1/00 – 2/1/02). Principal Investigator, funded by Department of Diagnostic Sciences, Texas A&M University College of Dentistry, Dallas, Texas

Selected Publications

Journal Articles

  • Patel PB*, Wright JM, Kang DR, and Cheng YSL. 2018, Longitudinal clinico-pathological data of the progression of oral mucosal melanoma-Report of two cases and literature review. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 126(1):e21-e30. doi: 10.1016/j.oooo.2017.12.015. PMID: 29429904 
  • Liu KY, Lu XJD, Cheng YSL, Klieb H, Ng S, McNeil K, Karsan A, and Poh CF. 2017, An actionable test using loss of heterozygosity in identifying high-risk oral premalignant lesions. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology pii: S2212-4403(17)31208-7. doi: 10.1016/j.oooo.2017.10.019. PMID: 29428696
  • McLean-Holden AC*, McPhillips A, and Cheng YSL. 2017, Oral and Maxillofacial Pathology Case of the Month: Hyperorthokeratosis with verrucous epithelial architecture; clinical and histological features suggestive of proliferative verrucous leukoplakia (PVL). Texas Dental Journal134(8): 468-9, 492-3.
  • Cheng YL, Jordan L, Chen HS, Kang D, Oxford L, Plemons J, Parks H, and Rees T. 2017, Chronic Periodontitis Can Affect the Levels of Potential Oral Cancer Salivary mRNA Biomarkers. Journal of Periodontal Research52(3):428-437. doi: 10.1111/jre.12407. PMID: 27549383
  • Cheng YL, Jordan L, Chen HS, Kang D, Oxford L, Plemons J, Parks H, and Rees T. 2017, Chronic Periodontitis Can Affect the Levels of Potential Oral Cancer Salivary mRNA Biomarkers. Journal of Periodontal Research 52(3):428-437. doi: 10.1111/jre.12407. PMID: 27549383
  • Ma P, Yan W, Tian Y, Wang J, Feng JQ, Qin C, Cheng YS, and Wang X. 2016, Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects. Scientific Reports 2016 Jul 13; 6:29814. doi: 10.1038/srep29814. PMID: 27405802
  •  Qari H, Pavelka J, and Cheng YSL. 2016, Oral and Maxillofacial Pathology Case of the Month: Cytomegalovirus associated oral ulceration. Texas Dental Journal 133(7):406-7, 428-30.
  • Malik BH, Lee J, Cheng S, Cuenca R, Jabbour JM, Cheng YL, Wright J, Ahmed B, Maitland KC, Jo JA. 2016, Objective Detection of Oral Carcinoma with Multispectral Fluorescence Lifetime Imaging In Vivo. Photochem Photobiol 92(5):694-701. doi: 10.1111/php.12627. PMID: 27499123
  • Cheng YSL, Gould A, Kurago Z, Fantasia J, and Muller S. 2016, Diagnosis of Oral Lichen Planus – A Position Paper of American Academy of Oral and Maxillofacial Pathology. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 122(3): 332-54. PMID: 27401683
  • Chi A, Katabi N, Chen HS, and Cheng YSL. 2016, Interobserver variation among pathologists in evaluating perineural invasion for oral squamous cell carcinoma, Head and Neck Pathology 10(4):451-64 PMID: 27140176
  • Childs SH, Kang DR, and Cheng YSL. 2016, Oral and Maxillofacial Pathology Case of the Month: Neurofibroma. Journal of the Michigan Dental Association
  • 98(5):42-5. PMID: 27333701
    Qari H, Hamao-Sakamoto A, Fuselier C, Cheng YSL, Kessler H, and Wright J. 2016, Phosphaturic Mesenchymal Tumor: 2 New Oral Cases and Review of 53 Cases in the Head and Neck. Head and Neck Pathology 10: 192-200. PMID: 26577211
  • Malik BH, Jabbour JM, Cheng S, Cuenca R, Cheng YSL, Wright JM, Jo JA, Maitland KC. 2016, A novel multimodal optical imaging system for early detection of oral cancer. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 121(3):290-300. PMID: 26725720
  • Cheng YSL, Rees T, Wright J. 2015, Updates regarding diagnostic adjuncts for oral squamous cell carcinoma. Texas Dental Journal 132(8): 538-49. PMID: 26489293
  • Childs SH, Kang DR, and Cheng YSL. 2015, Oral and Maxillofacial Pathology Case of the Month: Neurofibroma. Texas Dental Journal 132(5): 304-6, 328-9. PMID: 26234011
  • Phillips TD, Richardson M, Cheng YSL, He L, McDonald TJ, Cizmas LH, Safe SH, Donnelly KC, Wang F, Moorthy B, Zhou GD. 2015, Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol 89: 967-77. PMID: 24888377
  • Cheng YSL, Liang H, Wright J and Teenier J. 2015, Multiple orthokeratinized odontogenic cysts: a case report. Head and Neck Pathology 9:153-7. PMID: 24737103
  • Cheng YSL, Jordan L, Gorugantula LM, Schneiderman E, Chen HS, Rees TD. 2014, Salivary interleukin 6 and 8 in oral cancer patients and in patients with chronic oral inflammatory diseases. Journal of Periodontology 85(7): 956-65. PMID: 24147842
  • Liang H, Cheng YSL, Kessler H and Crossland J. 2014, Oral and Maxillofacial Pathology Case of the Month: Stafne defect. Journal of the Michigan Dental Association 96(8): 42-6. PMID: 25226678
  • Momen-Heravi F, Trachtenberg AJ, Kuo WP, and Cheng YSL. 2014, Genomewide Study of Salivary MicroRNAs for Detection of Oral Cancer. Journal of Dental Research 93(7 suppl): 86S-93S. PMID:24718111
  • Jabbour JM, Malik BH, Olsovsky C, Cuenca R, Cheng S, Jo JA, Cheng YSL, Wright JM, Maitland KC. 2014, Optical axial scanning in confocal microscopy using an electrically tunable lens. Biomed Opt Express 5(2): 645-52. PMID: 24575357
  • Cheng S, Cuenca RM, Liu B, Malik BH, Jabbour JM, Maitland KC, Wright J, Cheng YSL, Jo JA. 2014, Handheld multispectral fluorescence lifetime imaging system for in vivo applications. Biomed Opt Express 5(3):921-31. PMID: 24688824
  • Pande P, Shrestha S, Park J, Serafino MJ, Gimenez-Conti I, Brandon J, Cheng YSL, Applegate BE, Jo JA. 2014, Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch. J Biomed Opt 19(8): 086022. PMID: 25162909; PMCID: PMC4145245
  • Liang H, Cheng YSL, Kessler H and Crossland J. 2014, Oral and Maxillofacial Pathology Case of the Month: Stafne defect. Texas Dental Journal 131(2): 206-7, 254-6.
  • Cheng YSL, Rees T and Wright J. 2014, A review of research on salivary biomarkers for oral cancer detection.Clinical and Translational Medicine 3(1):3. PMID:24564868
  • Cheng YSL, Jordan L, Rees TD, Chen HS, Oxford L, Brinkmann O and Wong DT. 2013, Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients. Clinical Oral Investigation 18(3): 985-93. PMID: 2389249
  • Pugalagiri P, Muller S, Cox D, Kessler H, Wright J and Cheng YSL. 2013, Lymphangioma-like Kaposi sarcoma of the oral mucosa. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 116(1): 84-90. PMID: 23768875
  • Cheng S, Rico-Jimenez JJ, Jabbour J, Malik B, Maitland KC, Wright J, Cheng YSL, and Jo JA. 2013, Flexible endoscope for continuous in vivo multispectral fluorescence lifetime imaging. Optics Letters 38(9):1515-7. PMID: 2363253
  • Jabbour JM, Cheng S, Balik BH, Cuenca R, Jo JA, Wright J, Cheng YSL, and Maitland KC. 2013, Fluorescence lifetime imaging and reflectance confocal microscopy for multiscale imaging of oral precancer. J of Biomedical Optics 18(4): 046012. PMID: 23595826
  • Havard D, Cheng YSL, and Ellis M. 2012, Oral and Maxillofacial Pathology Case of the Month: Basal cell carcinoma, nodulo-ulcerative type. Texas Dental Journal 129(11): 1212-3, 1226-7. PMID: 23487893
  • Gorugantula L, Rees T, Plemons J, Chen HS and Cheng YSL. 2012, Salivary basic fibroblast growth factor in patients with oral squamous cell carcinoma or oral lichen planus. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 114(2): 215-22. PMID: 22769407
  • Liang H, Cheng YSL, Schwarz G. 2011, Oral and Maxillofacial Pathology Case of the Month: Antral pseudocyst. Texas Dental Journal 128(12): 1288, 1302-3. PMID: 22375447
  • Cheng YSL, Rees T, Jordan L, Oxford L, O’Brien J, Chen H, and Wong D. 2011, Salivary endothelin-1 potential in detecting oral cancer in patients with oral lichen planus or oral cancer in remission. Oral Oncology 47:1122-6.
  • Cheng YSL and Wright J. 2011, Advances in diagnostic adjuncts for oral squamous cell carcinoma. The Open Pathology Journal 5:3-7.
  • Cheng YSL, Caputo T and Plemons J, 2011, Oral and Maxillofacial Pathology Case of the Month: Ameloblastoma. Texas Dental Journal; 128(1): 102-3, 120-1.
  • Cheng YSL, Wright J, Lucente, J and McQuade, M. 2010, Oral and Maxillofacial Pathology Case of the Month: Verruciform Xanthoma. Texas Dental Journal; 127(1): 126-7, 130-1.
  • Lin Y, Cheng YSL, Qin C, Lin C, D’Souza R and Wang F. 2009, The epithelial FGFR2 is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors. Developmental Dynamics 238(2): 324-30.
  • Cheng YSL, Kessler H and Lucente J. 2008, Oral and Maxillofacial Pathology Case of the Month: Idiopathic Osteosclerosis. Texas Dental Journal 125(10): 1026-31.
  • Chang JYF, Stewart JM, Cheng YSL and Wright JM. 2008, Upper lip nodule /Merkel cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 105(5):549-53.
  • Cheng YSL, Liang H, Kessler H and Porter K. 2007, Oral and Maxillofacial Pathology Case of the Month: Langerhans Cell Histiocytosis. Texas Dental Journal 124(12): 1216-7, 1222-3.
  • Cheng YSL, Kessler H, Wright J, Lin JR, Lin LM, Huang E and Chen YK. 2007, Salivary gland malignancy with divergent differentiation: is it a teratocarcinosarcoma? Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 104: 82-8.
  • Cheng YSL, Kessler H, Watkins D, Watson S. 2007, Deep Penetrating Nevus of Cheek Skin. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 104: e49-e52.
  • Cheng YSL, Kessler H, Rees TD, Philofsky D and Pontikas A. 2007, Gingival swelling in a thirteen-year-old girl with multiple recurrences. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 103 (1): 85-91.
  • Cheng YSL, Mues G, Wood D and Ding JH. 2006. Aromatase expression in oral keratinocytes and oral squamous cell carcinoma. Archives of Oral Biology 51: 612-620.
  • Cheng YSL and Wright J. 2005, Oral and Maxillofacial Pathology Case of the Month: Focal cemento-osseous dysplasia. Texas Dental Journal September 122(9): 986-991.
  • Wen-Chen Wang, Cheng YSL, Chung-Ho Chen, Yu-Ru Lin, Yuk-Kwan Chen and Li-Min Lin. 2005, Paget’s disease of bone in a Chinese patient: A case report and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 99(6): 727-733.
  • Lin CC, Chen CH, Lin LM, Wright JM, Chen YK, Kessler HP, Cheng YSL, and Ellis E. 2004, Calcifying odontogenic cyst with ameloblastic fibroma. Report of three cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 98(4): 451-460.
  • Liang H, Frederiksen  NL, Binnie WH and Cheng YS. 2003, Intraosseous oral leiomyoma: systematic review and report of one case. Dentomaxillofacial Radiology 32: 285-290.
  • Cheng YSL and Wright J. 2003, Periapical lymphoma. Texas Dental Journal June 120(6): 497-500.
  • Cheng YSL, Binnie WH, Shroyer J and Bridges G. 2003, A forehead mass present for 53 years after trauma in childhood. Journal of Oral Pathology and Medicine 32(10): 612-617.
  • Cheng YSL, Wright JM, Walstad WR, and Finn MD. 2002, Osteosarcoma arising in Paget’s disease of mandible. Oral Oncology 38(8): 785-92.
  • Cheng YSL, Wright JM, Walstad WR, and Finn MD. 2002, Calcifying epithelial odontogenic tumor showing microscopic features of potential malignant behavior. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 93(3): 287-95.
  • Wright JM, Binnie WH and Cheng YSL. 2001, Oral cancer and precancer. Dental News 8(3): 29-34.
  • Cheng YSL, Rees TD, Wright JM, and Plemons JM. 2001, Childhood oral pemphigoid: a case report and review of the literature. Journal of Oral Pathology and Medicine 30: 372-377.
  • Cheng YSL, 1999, Photochemical crosslinking of collagen by 1, 8-naphthalimide. Ph.D. dissertation. Baylor University, Waco, Texas.
  • Cheng YSL, Matthews JL and Judy MM. 1999, Photochemical tissue welding. Chinese Dental Journal 18(4): 305-308.
  • Chen SY, Cheng YSL, and Tsai FM. 1994, Evaluation of industrial silicone rubber used in clinical dentistry. China Medical College Journal 4(1): 21-28.

 Book Chapters

  • Wright J, Kessler H, and Cheng, YSL, 2011, Mucosal and Related Dermatologic Diseases. In: Peterson’s Principles of Oral & Maxillofacial Surgery, 3rd edition. Editors: Miloro M, Ghali GE, Larsen P, and Walte P. People’s Medical Publishing House-USA.

Specialty Training/Board Certifications

  • 2005 - Western Regional Dental Examiner Board, Board certification
  • 2004 - National Dental Board, United States of America: Part II
  • 2003 - Diplomate of the American Board of Oral and Maxillofacial Pathology
  • 1997 - National Dental Board, United States of America: Part I
  • 1990 - National Dental Board, Taiwan

National Service/Recognition

  • 2017 – 2021    Member, Fellowship Committee, American Academy of Oral and Maxillofacial Pathology
  • 2017 – 2018    Consultant, Council on Scientific Affairs, American Dental Association
  • 2014 - 2015     Chair, Research and Scientific Affairs Committee, American Academy of Oral and Maxillofacial Pathology
  • 2010 - 2015     Member, Research and Scientific Affairs Committee, American Academy of Oral and Maxillofacial Pathology
  • 2008 - 2010     Member, Audio Visual Committee, American Academy of Oral and Maxillofacial Pathology
  • 2009                Vice President, Dallas Asian Dental Association
  • 2008 - 2009     President, Texas Association of Women Dentist
  • 2008                Chair for Continuing Education, Dallas Asian Dental Association

Grant Reviewer

  • 2018                American Academy of Oral and Maxillofacial Pathology Research Grant
  • 2016                NIH NIDCR Clinical Trial or Biomarker Clinical Validation Study Cooperative Agreement (U01)
  • 2015                NIH NIDCR Clinical Trial or Biomarker Clinical Validation Study Planning Grant (R34)
  • 2015                NIH Small Business Innovative Research Grants (SBIR) 
  • 2009                NIH Recovery Act Limited Competition, Challenge Grants in Health and Science Research (RC1)

Invited Speaker

  • “Diagnosis of Oral Lichen Planus”, Academic Conference of Chinese Society of Oral Pathology, Taiyuan, Shanxi, China, September 14, 2018
  • “Bone Pathology”, Congreso Nacional E Internacional De La Facultad de Odontología (National and International Dental School Meeting), National Autonomous University of Mexico, Mexico City, Mexico, May 4, 2018
  • “Salivary Biomarkers for Oral Cancer Detection”, Western Society of Teachers of Oral Pathology, Sedona, AZ, September 30, 2017
  • “Dental Education and Oral and Maxillofacial Pathology Residency Program in the US – Using Baylor College of Dentistry as an Example”, Shanxi Medical University, China, July 19, 2016
  • “My Experience in Clinical Research” in Clinical Research: A Panel Discussion, Faculty Development and Networking Series, Texas A&M University – Baylor College of Dentistry, Dallas, TX. August 26, 2015
  • “Directions in Research on Salivary Biomarkers for Oral Cancer Detection”. The 37th Annual Scientific Meeting, Associations for Dental Sciences of the Republic of China, Taipei, Taiwan. October 26, 2014
  • “Advances in Diagnostic Adjuncts for Oral Squamous Cell Carcinoma”, Southwest Dental Conference / CE Express, Dallas, TX, January 13, 2011
  • “An Analysis of Differences Between Representative DDS Programs in the US and in Taiwan”, in Annual Scientific Meeting of the Association for Dental Sciences of the Republic of China, Taipei, Taiwan, November 28, 2008

Editorial Board and Journal Reviewer

  • 2017                Reviewer for Archives of Oral Biology
  • 2016-2019       Editorial Board, Head and Neck Pathology
  • 2016                Reviewer for Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
  •                         Reviewer for Oral Pathology and Medicine
  • 2015                Reviewer for Archives of Oral Biology
  •                         Reviewer for Scientific Reports
  • 2014                Reviewer for Journal of Innovative Optical Health Sciences
  • 2013                Reviewer for Head and Neck Pathology
  •                         Reviewer for International Journal of Oral Science
  •                         Reviewer for Journal of Oral Pathology and Medicine
  • 2012                Reviewer for Head and Neck Pathology
  •                         Reviewer for Regulatory Peptides
  • 2011                Reviewer for Journal of Oral and Maxillofacial Pathology
  • 2009-2012       Editorial Board, Head and Neck Pathology
  • 2008                Reviewer for Head and Neck Pathology